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The evidence of low-intensity pulsed ultrasound for in vitro, animal and human fracture healing
Background Physical stimulation therapies are currently available to enhance fracture healing. Sources of data A search of PubMed, Medline, CINAHL, DH data and Embase databases was performed using the keywords 'ultrasound' and 'fracture healing'. Areas of agreement The evidence i...
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| Published in: | British medical bulletin 2011-12, Vol.100 (1), p.39-57 |
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| Main Authors: | , , , , |
| Format: | Article |
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| container_title | British medical bulletin |
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| creator | Martinez de Albornoz, Pilar Khanna, Anil Longo, Umile Giuseppe Forriol, Francisco Maffulli, Nicola |
| description | Background
Physical stimulation therapies are currently available to enhance fracture healing.
Sources of data
A search of PubMed, Medline, CINAHL, DH data and Embase databases was performed using the keywords 'ultrasound' and 'fracture healing'.
Areas of agreement
The evidence in vitro and animal studies suggests that low-intensity pulsed ultrasound (LIPUS) produces significant osteoinductive effects, accelerating the healing process and improving the bone-bending strength.
Areas of controversy
The evidence in human trials is controversial in fresh, stress fractures and in limb lengthening. LIPUS is effective in delayed unions, in smokers and in diabetic population.
Growing points
LIPUS is an alternative, less invasive form of treatment for complicated fractures, in patients with poor bone healing and may play a role in the management of large-scale bone defects producing substantial cost savings and decreasing associated disability.
Areas timely for developing research
There is heterogeneity among in vitro, animal studies and their application to human studies. Further randomized controlled trials of high methodological quality are needed. |
| doi_str_mv | 10.1093/bmb/ldr006 |
| format | article |
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Physical stimulation therapies are currently available to enhance fracture healing.
Sources of data
A search of PubMed, Medline, CINAHL, DH data and Embase databases was performed using the keywords 'ultrasound' and 'fracture healing'.
Areas of agreement
The evidence in vitro and animal studies suggests that low-intensity pulsed ultrasound (LIPUS) produces significant osteoinductive effects, accelerating the healing process and improving the bone-bending strength.
Areas of controversy
The evidence in human trials is controversial in fresh, stress fractures and in limb lengthening. LIPUS is effective in delayed unions, in smokers and in diabetic population.
Growing points
LIPUS is an alternative, less invasive form of treatment for complicated fractures, in patients with poor bone healing and may play a role in the management of large-scale bone defects producing substantial cost savings and decreasing associated disability.
Areas timely for developing research
There is heterogeneity among in vitro, animal studies and their application to human studies. Further randomized controlled trials of high methodological quality are needed.</description><identifier>ISSN: 0007-1420</identifier><identifier>EISSN: 1471-8391</identifier><identifier>DOI: 10.1093/bmb/ldr006</identifier><identifier>PMID: 21429948</identifier><identifier>CODEN: BMBUAQ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Biological and medical sciences ; Disease Models, Animal ; Evidence-Based Medicine - methods ; Fracture Healing - radiation effects ; Fractures, Bone - physiopathology ; Fractures, Bone - therapy ; General aspects ; Humans ; Medical sciences ; Treatment Outcome ; Ultrasonic Therapy - methods</subject><ispartof>British medical bulletin, 2011-12, Vol.100 (1), p.39-57</ispartof><rights>The Author 2011. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-a0979e3b4cfa8e964d30666c333a620954602c43ae8d4bc8f367aaa13b857b243</citedby><cites>FETCH-LOGICAL-c481t-a0979e3b4cfa8e964d30666c333a620954602c43ae8d4bc8f367aaa13b857b243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25285390$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21429948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martinez de Albornoz, Pilar</creatorcontrib><creatorcontrib>Khanna, Anil</creatorcontrib><creatorcontrib>Longo, Umile Giuseppe</creatorcontrib><creatorcontrib>Forriol, Francisco</creatorcontrib><creatorcontrib>Maffulli, Nicola</creatorcontrib><title>The evidence of low-intensity pulsed ultrasound for in vitro, animal and human fracture healing</title><title>British medical bulletin</title><addtitle>Br Med Bull</addtitle><description>Background
Physical stimulation therapies are currently available to enhance fracture healing.
Sources of data
A search of PubMed, Medline, CINAHL, DH data and Embase databases was performed using the keywords 'ultrasound' and 'fracture healing'.
Areas of agreement
The evidence in vitro and animal studies suggests that low-intensity pulsed ultrasound (LIPUS) produces significant osteoinductive effects, accelerating the healing process and improving the bone-bending strength.
Areas of controversy
The evidence in human trials is controversial in fresh, stress fractures and in limb lengthening. LIPUS is effective in delayed unions, in smokers and in diabetic population.
Growing points
LIPUS is an alternative, less invasive form of treatment for complicated fractures, in patients with poor bone healing and may play a role in the management of large-scale bone defects producing substantial cost savings and decreasing associated disability.
Areas timely for developing research
There is heterogeneity among in vitro, animal studies and their application to human studies. Further randomized controlled trials of high methodological quality are needed.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Evidence-Based Medicine - methods</subject><subject>Fracture Healing - radiation effects</subject><subject>Fractures, Bone - physiopathology</subject><subject>Fractures, Bone - therapy</subject><subject>General aspects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Treatment Outcome</subject><subject>Ultrasonic Therapy - methods</subject><issn>0007-1420</issn><issn>1471-8391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp90EFLHDEUwPFQKnWrvfQDSC6lRRx9mWQzyVGktYLgRc_Dm0ymm5JJ1mRi8ds3stt68_Qg_HiP_An5zOCcgeYXwzxc-DEByHdkxUTHGsU1e09WANA1TLRwSD7m_BuAcQ7qAzls66PWQq1If7-x1D650QZjaZyoj38aFxYbslue6bb4bEda_JIwxxJGOsVEXaBPbknxjGJwM_o6RropMwY6JTRLSZZuLHoXfh2Tgwnrjk_7eUQefny_v_rZ3N5d31xd3jZGKLY0CLrTlg_CTKislmLkIKU0nHOULei1kNAawdGqUQxGTVx2iMj4oNbd0Ap-RL7u9m5TfCw2L_3ssrHeY7Cx5F4zpnmtpav89qZk0CroNOtkpac7alLMOdmp36b63_RcUf-Svq_p-136ik_2e8sw2_E__de6gi97gNmgr6WCcfnVrVu15hpeXSzbtw7-BRfYmOk</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Martinez de Albornoz, Pilar</creator><creator>Khanna, Anil</creator><creator>Longo, Umile Giuseppe</creator><creator>Forriol, Francisco</creator><creator>Maffulli, Nicola</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>The evidence of low-intensity pulsed ultrasound for in vitro, animal and human fracture healing</title><author>Martinez de Albornoz, Pilar ; Khanna, Anil ; Longo, Umile Giuseppe ; Forriol, Francisco ; Maffulli, Nicola</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-a0979e3b4cfa8e964d30666c333a620954602c43ae8d4bc8f367aaa13b857b243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Evidence-Based Medicine - methods</topic><topic>Fracture Healing - radiation effects</topic><topic>Fractures, Bone - physiopathology</topic><topic>Fractures, Bone - therapy</topic><topic>General aspects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Treatment Outcome</topic><topic>Ultrasonic Therapy - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martinez de Albornoz, Pilar</creatorcontrib><creatorcontrib>Khanna, Anil</creatorcontrib><creatorcontrib>Longo, Umile Giuseppe</creatorcontrib><creatorcontrib>Forriol, Francisco</creatorcontrib><creatorcontrib>Maffulli, Nicola</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British medical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martinez de Albornoz, Pilar</au><au>Khanna, Anil</au><au>Longo, Umile Giuseppe</au><au>Forriol, Francisco</au><au>Maffulli, Nicola</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The evidence of low-intensity pulsed ultrasound for in vitro, animal and human fracture healing</atitle><jtitle>British medical bulletin</jtitle><addtitle>Br Med Bull</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>100</volume><issue>1</issue><spage>39</spage><epage>57</epage><pages>39-57</pages><issn>0007-1420</issn><eissn>1471-8391</eissn><coden>BMBUAQ</coden><abstract>Background
Physical stimulation therapies are currently available to enhance fracture healing.
Sources of data
A search of PubMed, Medline, CINAHL, DH data and Embase databases was performed using the keywords 'ultrasound' and 'fracture healing'.
Areas of agreement
The evidence in vitro and animal studies suggests that low-intensity pulsed ultrasound (LIPUS) produces significant osteoinductive effects, accelerating the healing process and improving the bone-bending strength.
Areas of controversy
The evidence in human trials is controversial in fresh, stress fractures and in limb lengthening. LIPUS is effective in delayed unions, in smokers and in diabetic population.
Growing points
LIPUS is an alternative, less invasive form of treatment for complicated fractures, in patients with poor bone healing and may play a role in the management of large-scale bone defects producing substantial cost savings and decreasing associated disability.
Areas timely for developing research
There is heterogeneity among in vitro, animal studies and their application to human studies. Further randomized controlled trials of high methodological quality are needed.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>21429948</pmid><doi>10.1093/bmb/ldr006</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British medical bulletin, 2011-12, Vol.100 (1), p.39-57 |
| issn | 0007-1420 1471-8391 |
| language | eng |
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| source | Oxford Journals Online |
| subjects | Animals Biological and medical sciences Disease Models, Animal Evidence-Based Medicine - methods Fracture Healing - radiation effects Fractures, Bone - physiopathology Fractures, Bone - therapy General aspects Humans Medical sciences Treatment Outcome Ultrasonic Therapy - methods |
| title | The evidence of low-intensity pulsed ultrasound for in vitro, animal and human fracture healing |
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