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In situ follicular lymphoma with progressive transformation of the germinal centers confirmed by laser capture microdissection, IGH gene rearrangement analysis, and fluorescence in situ hybridization for t(14;18)
Summary The authors report an unusual case of in situ follicular lymphoma associated with progressive transformation of the germinal centers. The patient was a 74-year-old Chinese woman with sequential lymphadenopathy in the right and left cervical regions over a period of 2 months. The first biopsy...
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| Published in: | Human pathology 2012, Vol.43 (1), p.138-143 |
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| container_end_page | 143 |
| container_issue | 1 |
| container_start_page | 138 |
| container_title | Human pathology |
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| creator | Li, Jin-nan, MD Zhang, Wen-yan, MD Tang, Yuan, MD Li, Gan-di, MD Dong, Dan-dan, MD |
| description | Summary The authors report an unusual case of in situ follicular lymphoma associated with progressive transformation of the germinal centers. The patient was a 74-year-old Chinese woman with sequential lymphadenopathy in the right and left cervical regions over a period of 2 months. The first biopsy revealed in situ follicular lymphoma with progressive transformation of germinal centers, and the biopsy of the second lymph node led to a diagnosis of in situ follicular lymphoma. The immunophenotype, polymerase chain reaction amplification of the immunoglobulin heavy chain gene, and fluorescence in situ hybridization for t(14;18) were analyzed in each biopsy specimen, which showed both specimens to have t(14;18)(q32;q21) and revealed progression from polyclonality to monoclonality. These findings suggest a case of multicentric in situ follicular lymphoma and provide new insights into the pathogenesis of this disease. |
| doi_str_mv | 10.1016/j.humpath.2011.01.035 |
| format | article |
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The patient was a 74-year-old Chinese woman with sequential lymphadenopathy in the right and left cervical regions over a period of 2 months. The first biopsy revealed in situ follicular lymphoma with progressive transformation of germinal centers, and the biopsy of the second lymph node led to a diagnosis of in situ follicular lymphoma. The immunophenotype, polymerase chain reaction amplification of the immunoglobulin heavy chain gene, and fluorescence in situ hybridization for t(14;18) were analyzed in each biopsy specimen, which showed both specimens to have t(14;18)(q32;q21) and revealed progression from polyclonality to monoclonality. These findings suggest a case of multicentric in situ follicular lymphoma and provide new insights into the pathogenesis of this disease.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2011.01.035</identifier><identifier>PMID: 21733560</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Biological and medical sciences ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - pathology ; Chromosome aberrations ; Chromosomes ; Chromosomes, Human, Pair 14 ; Chromosomes, Human, Pair 18 ; Clone Cells ; Disease Progression ; Female ; Gene Rearrangement ; Germinal Center - pathology ; Hematologic and hematopoietic diseases ; Histology ; Humans ; Hybridization ; Immunoglobulin Heavy Chains - genetics ; Immunophenotyping ; In situ follicular lymphoma ; In Situ Hybridization, Fluorescence - methods ; Investigative techniques, diagnostic techniques (general aspects) ; Laser Capture Microdissection ; Lasers ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphatic system ; Lymphocytes ; Lymphoma ; Lymphoma - genetics ; Lymphoma - pathology ; Lymphoma, Follicular - genetics ; Lymphoma, Follicular - pathology ; Medical genetics ; Medical sciences ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Progressive transformation of germinal centers ; t(14;18)(q32;q21) ; Translocation, Genetic</subject><ispartof>Human pathology, 2012, Vol.43 (1), p.138-143</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-222886a0ffee46a4d19fce8972f29eaf94e7bcca1d8b49783e6af9a96c50d82c3</citedby><cites>FETCH-LOGICAL-c477t-222886a0ffee46a4d19fce8972f29eaf94e7bcca1d8b49783e6af9a96c50d82c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25604684$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21733560$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Jin-nan, MD</creatorcontrib><creatorcontrib>Zhang, Wen-yan, MD</creatorcontrib><creatorcontrib>Tang, Yuan, MD</creatorcontrib><creatorcontrib>Li, Gan-di, MD</creatorcontrib><creatorcontrib>Dong, Dan-dan, MD</creatorcontrib><title>In situ follicular lymphoma with progressive transformation of the germinal centers confirmed by laser capture microdissection, IGH gene rearrangement analysis, and fluorescence in situ hybridization for t(14;18)</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary The authors report an unusual case of in situ follicular lymphoma associated with progressive transformation of the germinal centers. The patient was a 74-year-old Chinese woman with sequential lymphadenopathy in the right and left cervical regions over a period of 2 months. The first biopsy revealed in situ follicular lymphoma with progressive transformation of germinal centers, and the biopsy of the second lymph node led to a diagnosis of in situ follicular lymphoma. The immunophenotype, polymerase chain reaction amplification of the immunoglobulin heavy chain gene, and fluorescence in situ hybridization for t(14;18) were analyzed in each biopsy specimen, which showed both specimens to have t(14;18)(q32;q21) and revealed progression from polyclonality to monoclonality. These findings suggest a case of multicentric in situ follicular lymphoma and provide new insights into the pathogenesis of this disease.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Chromosome aberrations</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 14</subject><subject>Chromosomes, Human, Pair 18</subject><subject>Clone Cells</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gene Rearrangement</subject><subject>Germinal Center - pathology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Histology</subject><subject>Humans</subject><subject>Hybridization</subject><subject>Immunoglobulin Heavy Chains - genetics</subject><subject>Immunophenotyping</subject><subject>In situ follicular lymphoma</subject><subject>In Situ Hybridization, Fluorescence - methods</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Laser Capture Microdissection</subject><subject>Lasers</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Lymphoma</subject><subject>Lymphoma - genetics</subject><subject>Lymphoma - pathology</subject><subject>Lymphoma, Follicular - genetics</subject><subject>Lymphoma, Follicular - pathology</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Progressive transformation of germinal centers</subject><subject>t(14;18)(q32;q21)</subject><subject>Translocation, Genetic</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFkl-L1DAUxYso7rr6EZSAiAo7Y_61TREUWXR3YMEH9Tlk0puZjGkzJu1K_Zx-IG-Z0YV9EQIJ5ZfTk3NuUTxldMkoq97sltux25thu-SUsSXFJcp7xSkrBV8o0fD7xSmlslooVtcnxaOcdxTBUpYPixPOaiHKip4Wv1c9yX4YiYsheDsGk0iYuv02dob89MOW7FPcJMjZ3wAZkumzi6kzg489iY4MWyAbSJ3vTSAW-gFSJjb2zqcOWrKeSDAZErFmP4wJSOdtiq3PGewscU5Wl1co0ANJYBLKb6BDFWJQb8o-n-OpJS6MET2gvgXij4630zr51v86eEFXZHjF5FumXj8uHjgTMjw57mfFt08fv15cLa4_X64uPlwvrKzrYcE5V6oy1DkAWRnZssZZUE3NHW_AuEZCvbbWsFatZVMrARV-NE1lS9oqbsVZ8fKgixn9GCEPuvNoMgTTQxyzbhhrBFcVR_L5HXIXx4RvzJpRIVXDGimQKg8UZpRzAqf3yXcmTQjpuXW908fW9dy6prhEifeeHdXHNab-79bfmhF4cQRMtiY4zNn6fMshIyslkXt_4ABTu_GQdLZ-Dr31CQvTbfT_tfLujoINvvf40-8wQb59tc5cU_1lHtF5QhnD6SxlLf4AADTn0Q</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Li, Jin-nan, MD</creator><creator>Zhang, Wen-yan, MD</creator><creator>Tang, Yuan, MD</creator><creator>Li, Gan-di, MD</creator><creator>Dong, Dan-dan, MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>In situ follicular lymphoma with progressive transformation of the germinal centers confirmed by laser capture microdissection, IGH gene rearrangement analysis, and fluorescence in situ hybridization for t(14;18)</title><author>Li, Jin-nan, MD ; Zhang, Wen-yan, MD ; Tang, Yuan, MD ; Li, Gan-di, MD ; Dong, Dan-dan, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-222886a0ffee46a4d19fce8972f29eaf94e7bcca1d8b49783e6af9a96c50d82c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Chromosome aberrations</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, Pair 14</topic><topic>Chromosomes, Human, Pair 18</topic><topic>Clone Cells</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Gene Rearrangement</topic><topic>Germinal Center - pathology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Histology</topic><topic>Humans</topic><topic>Hybridization</topic><topic>Immunoglobulin Heavy Chains - genetics</topic><topic>Immunophenotyping</topic><topic>In situ follicular lymphoma</topic><topic>In Situ Hybridization, Fluorescence - methods</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Laser Capture Microdissection</topic><topic>Lasers</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphatic system</topic><topic>Lymphocytes</topic><topic>Lymphoma</topic><topic>Lymphoma - genetics</topic><topic>Lymphoma - pathology</topic><topic>Lymphoma, Follicular - genetics</topic><topic>Lymphoma, Follicular - pathology</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Progressive transformation of germinal centers</topic><topic>t(14;18)(q32;q21)</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jin-nan, MD</creatorcontrib><creatorcontrib>Zhang, Wen-yan, MD</creatorcontrib><creatorcontrib>Tang, Yuan, MD</creatorcontrib><creatorcontrib>Li, Gan-di, MD</creatorcontrib><creatorcontrib>Dong, Dan-dan, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jin-nan, MD</au><au>Zhang, Wen-yan, MD</au><au>Tang, Yuan, MD</au><au>Li, Gan-di, MD</au><au>Dong, Dan-dan, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In situ follicular lymphoma with progressive transformation of the germinal centers confirmed by laser capture microdissection, IGH gene rearrangement analysis, and fluorescence in situ hybridization for t(14;18)</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2012</date><risdate>2012</risdate><volume>43</volume><issue>1</issue><spage>138</spage><epage>143</epage><pages>138-143</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Summary The authors report an unusual case of in situ follicular lymphoma associated with progressive transformation of the germinal centers. The patient was a 74-year-old Chinese woman with sequential lymphadenopathy in the right and left cervical regions over a period of 2 months. The first biopsy revealed in situ follicular lymphoma with progressive transformation of germinal centers, and the biopsy of the second lymph node led to a diagnosis of in situ follicular lymphoma. The immunophenotype, polymerase chain reaction amplification of the immunoglobulin heavy chain gene, and fluorescence in situ hybridization for t(14;18) were analyzed in each biopsy specimen, which showed both specimens to have t(14;18)(q32;q21) and revealed progression from polyclonality to monoclonality. These findings suggest a case of multicentric in situ follicular lymphoma and provide new insights into the pathogenesis of this disease.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21733560</pmid><doi>10.1016/j.humpath.2011.01.035</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Chromosome aberrations Chromosomes Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 18 Clone Cells Disease Progression Female Gene Rearrangement Germinal Center - pathology Hematologic and hematopoietic diseases Histology Humans Hybridization Immunoglobulin Heavy Chains - genetics Immunophenotyping In situ follicular lymphoma In Situ Hybridization, Fluorescence - methods Investigative techniques, diagnostic techniques (general aspects) Laser Capture Microdissection Lasers Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic system Lymphocytes Lymphoma Lymphoma - genetics Lymphoma - pathology Lymphoma, Follicular - genetics Lymphoma, Follicular - pathology Medical genetics Medical sciences Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Progressive transformation of germinal centers t(14 18)(q32 q21) Translocation, Genetic |
| title | In situ follicular lymphoma with progressive transformation of the germinal centers confirmed by laser capture microdissection, IGH gene rearrangement analysis, and fluorescence in situ hybridization for t(14;18) |
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