Chemical stability and degradation mechanisms of ferulic acid (F.A) within various cosmetic formulations

Ferulic acid (F.A) receives significant interest in the beauty industry with regard to its skin-whitening and anti-oxidant properties. However, its use in cosmetics is limited due to pH- and temperature-related instabilities. In this study, we investigated the stability of F.A in eight different pro...

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Published in:Journal of cosmetic science 2011-09, Vol.62 (5), p.483-503
Main Authors: Wang, Qiu-Jing, Gao, Xiang, Gong, Hui, Lin, Xin-Rong, Saint-Leger, Didier, Senee, Jerome
Format: Article
Language:English
Subjects:
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Cosmetics - chemistry
Coumaric Acids - chemistry
Drug Stability
Humans
Solvents - chemistry
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container_issue 5
container_start_page 483
container_title Journal of cosmetic science
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creator Wang, Qiu-Jing
Gao, Xiang
Gong, Hui
Lin, Xin-Rong
Saint-Leger, Didier
Senee, Jerome
description Ferulic acid (F.A) receives significant interest in the beauty industry with regard to its skin-whitening and anti-oxidant properties. However, its use in cosmetics is limited due to pH- and temperature-related instabilities. In this study, we investigated the stability of F.A in eight different prototype formulae. The results confirmed that in our conditions the stability of F.A is pH- and temperature-related. Additionally, the nature of the solvent dipropylene glycol (DPPG) showed a capacity to stabilize F.A. A series of experiments was further planned for studying the mechanism of degradation of F.A. In a prototype of a cosmetic medium, F.A degrades first through a decarboxylation step, leading to 4-hydroxy-3-methoxystyrene (PVG). Further, F.A and PVG are both involved in an additional reaction, resulting in the trans-conjugation dimer of PVG. The consequences of these results in formulating F.A are discussed.
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subjects Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Cosmetics - chemistry
Coumaric Acids - chemistry
Drug Stability
Humans
Solvents - chemistry
title Chemical stability and degradation mechanisms of ferulic acid (F.A) within various cosmetic formulations
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