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Histologic Type Predicts Survival in Patients with Retroperitoneal Soft Tissue Sarcoma
Background Histologic grade, completeness of resection, and presence of metastases are traditionally regarded as the primary factors in predicting survival for retroperitoneal soft tissue sarcoma (RPSTS). We sought to examine the importance of histologic type as a prognostic factor among patients wi...
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| Published in: | The Journal of surgical research 2012, Vol.172 (1), p.123-130 |
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| creator | Tseng, Warren, M.D Martinez, Steve R., M.D., M.A.S Tamurian, Robert M., M.D Borys, Dariusz, M.D Canter, Robert J., M.D |
| description | Background Histologic grade, completeness of resection, and presence of metastases are traditionally regarded as the primary factors in predicting survival for retroperitoneal soft tissue sarcoma (RPSTS). We sought to examine the importance of histologic type as a prognostic factor among patients with RPSTS. Methods We identified 2337 cases of RPSTS in the Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2004. After excluding 273 cases of age |
| doi_str_mv | 10.1016/j.jss.2010.07.056 |
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We sought to examine the importance of histologic type as a prognostic factor among patients with RPSTS. Methods We identified 2337 cases of RPSTS in the Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2004. After excluding 273 cases of age <18, identification by autopsy only, or absence of histologic confirmation, we arrived at a final study cohort of 2064 patients. Overall survival (OS) and disease-specific survival (DSS) were estimated using the Kaplan-Meier method. Multivariate analysis was performed using a Cox proportional hazards model, adjusting for age, gender, race, histologic type, histologic grade, tumor size, extent of resection, and SEER summary stage. Results Among 33 histologic types, leiomyosarcoma (28.7%), well-differentiated/dedifferentiated liposarcoma (20.3%), liposarcoma not otherwise specified (NOS) (11.9%), malignant fibrous histiocytoma (MFH–11.0%), and sarcoma NOS (10.7%) were the most prevalent. Grade distribution was low, 24.2%; intermediate, 16%; high 34.3%, and unknown, 25.5%. Surgery was performed in 85.8%, and radiotherapy was administered to 22.8%. With a median follow-up of 38 mo, median OS was 78, 35, 25, 18, and 10 mo for liposarcoma, leiomyosarcoma, other histologies, MFH, and sarcoma NOS, respectively ( P < 0.0001). Median DSS was 120, 53, not reached, 30, and 13 mo for liposarcoma, leiomyosarcoma, other histologies, MFH, and sarcoma NOS, respectively ( P < 0.0001). On multivariate analysis, histologic type was associated with statistically significant differences in both OS and DSS. Conclusions Histologic type is an important predictor of survival in RPSTS.</description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/j.jss.2010.07.056</identifier><identifier>PMID: 20869082</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Female ; Histiocytoma, Malignant Fibrous - diagnosis ; Histiocytoma, Malignant Fibrous - mortality ; Histiocytoma, Malignant Fibrous - pathology ; Humans ; Kaplan-Meier Estimate ; Leiomyosarcoma - diagnosis ; Leiomyosarcoma - mortality ; Leiomyosarcoma - pathology ; Liposarcoma - diagnosis ; Liposarcoma - mortality ; Liposarcoma - pathology ; Male ; Middle Aged ; Multivariate Analysis ; Predictive Value of Tests ; Prognosis ; Retroperitoneal Neoplasms - diagnosis ; Retroperitoneal Neoplasms - mortality ; Retroperitoneal Neoplasms - pathology ; Retrospective Studies ; Sarcoma - diagnosis ; Sarcoma - mortality ; Sarcoma - pathology ; SEER Program ; Surgery ; Survival Rate ; United States</subject><ispartof>The Journal of surgical research, 2012, Vol.172 (1), p.123-130</ispartof><rights>Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-bfa2e740cb753232f1f40f1bbd22a6e06d201c42b6516b729fb65947fd14584d3</citedby><cites>FETCH-LOGICAL-c355t-bfa2e740cb753232f1f40f1bbd22a6e06d201c42b6516b729fb65947fd14584d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20869082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tseng, Warren, M.D</creatorcontrib><creatorcontrib>Martinez, Steve R., M.D., M.A.S</creatorcontrib><creatorcontrib>Tamurian, Robert M., M.D</creatorcontrib><creatorcontrib>Borys, Dariusz, M.D</creatorcontrib><creatorcontrib>Canter, Robert J., M.D</creatorcontrib><title>Histologic Type Predicts Survival in Patients with Retroperitoneal Soft Tissue Sarcoma</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description>Background Histologic grade, completeness of resection, and presence of metastases are traditionally regarded as the primary factors in predicting survival for retroperitoneal soft tissue sarcoma (RPSTS). We sought to examine the importance of histologic type as a prognostic factor among patients with RPSTS. Methods We identified 2337 cases of RPSTS in the Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2004. After excluding 273 cases of age <18, identification by autopsy only, or absence of histologic confirmation, we arrived at a final study cohort of 2064 patients. Overall survival (OS) and disease-specific survival (DSS) were estimated using the Kaplan-Meier method. Multivariate analysis was performed using a Cox proportional hazards model, adjusting for age, gender, race, histologic type, histologic grade, tumor size, extent of resection, and SEER summary stage. Results Among 33 histologic types, leiomyosarcoma (28.7%), well-differentiated/dedifferentiated liposarcoma (20.3%), liposarcoma not otherwise specified (NOS) (11.9%), malignant fibrous histiocytoma (MFH–11.0%), and sarcoma NOS (10.7%) were the most prevalent. Grade distribution was low, 24.2%; intermediate, 16%; high 34.3%, and unknown, 25.5%. Surgery was performed in 85.8%, and radiotherapy was administered to 22.8%. With a median follow-up of 38 mo, median OS was 78, 35, 25, 18, and 10 mo for liposarcoma, leiomyosarcoma, other histologies, MFH, and sarcoma NOS, respectively ( P < 0.0001). Median DSS was 120, 53, not reached, 30, and 13 mo for liposarcoma, leiomyosarcoma, other histologies, MFH, and sarcoma NOS, respectively ( P < 0.0001). On multivariate analysis, histologic type was associated with statistically significant differences in both OS and DSS. Conclusions Histologic type is an important predictor of survival in RPSTS.</description><subject>Aged</subject><subject>Female</subject><subject>Histiocytoma, Malignant Fibrous - diagnosis</subject><subject>Histiocytoma, Malignant Fibrous - mortality</subject><subject>Histiocytoma, Malignant Fibrous - pathology</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Leiomyosarcoma - diagnosis</subject><subject>Leiomyosarcoma - mortality</subject><subject>Leiomyosarcoma - pathology</subject><subject>Liposarcoma - diagnosis</subject><subject>Liposarcoma - mortality</subject><subject>Liposarcoma - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retroperitoneal Neoplasms - diagnosis</subject><subject>Retroperitoneal Neoplasms - mortality</subject><subject>Retroperitoneal Neoplasms - pathology</subject><subject>Retrospective Studies</subject><subject>Sarcoma - diagnosis</subject><subject>Sarcoma - mortality</subject><subject>Sarcoma - pathology</subject><subject>SEER Program</subject><subject>Surgery</subject><subject>Survival Rate</subject><subject>United States</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNo9kUtr3DAUhUVoSKZJf0A3wbuuPL2SZcneBErIoxBI6Ey6FbJ81cjxWFNJnjL_vhom7eo-OPfC-Q4hnyksKVDxdVgOMS4Z5BnkEmpxQhYU2rpshKw-kAUAYyVvgJ-TjzEOkOdWVmfknEEjWmjYgvx8cDH50f9ypljvt1g8B-ydSbFYzWHndnos3FQ86-Rwyss_Lr0WPzAFv8Xgkp8wC1bepmLtYpyxWOlg_EZfklOrx4if3usFebm7Xd88lI9P999vvj2WpqrrVHZWM5QcTCfrilXMUsvB0q7rGdMCQfTZnOGsEzUVnWStzV3Lpe0prxveVxfky_HvNvjfM8akNi4aHEc9oZ-jailtK9kKmpX0qDTBxxjQqm1wGx32ioI60FSDyjTVgaYCqTLNfHP1_n3uNtj_v_iHLwuujwLMHncOgzKjm5zR4xvuMQ5-DlO2r6iKTIFaHQI55EFzFEIyXv0F9SCGYg</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Tseng, Warren, M.D</creator><creator>Martinez, Steve R., M.D., M.A.S</creator><creator>Tamurian, Robert M., M.D</creator><creator>Borys, Dariusz, M.D</creator><creator>Canter, Robert J., M.D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Histologic Type Predicts Survival in Patients with Retroperitoneal Soft Tissue Sarcoma</title><author>Tseng, Warren, M.D ; Martinez, Steve R., M.D., M.A.S ; Tamurian, Robert M., M.D ; Borys, Dariusz, M.D ; Canter, Robert J., M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-bfa2e740cb753232f1f40f1bbd22a6e06d201c42b6516b729fb65947fd14584d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Female</topic><topic>Histiocytoma, Malignant Fibrous - diagnosis</topic><topic>Histiocytoma, Malignant Fibrous - mortality</topic><topic>Histiocytoma, Malignant Fibrous - pathology</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Leiomyosarcoma - diagnosis</topic><topic>Leiomyosarcoma - mortality</topic><topic>Leiomyosarcoma - pathology</topic><topic>Liposarcoma - diagnosis</topic><topic>Liposarcoma - mortality</topic><topic>Liposarcoma - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Retroperitoneal Neoplasms - diagnosis</topic><topic>Retroperitoneal Neoplasms - mortality</topic><topic>Retroperitoneal Neoplasms - pathology</topic><topic>Retrospective Studies</topic><topic>Sarcoma - diagnosis</topic><topic>Sarcoma - mortality</topic><topic>Sarcoma - pathology</topic><topic>SEER Program</topic><topic>Surgery</topic><topic>Survival Rate</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tseng, Warren, M.D</creatorcontrib><creatorcontrib>Martinez, Steve R., M.D., M.A.S</creatorcontrib><creatorcontrib>Tamurian, Robert M., M.D</creatorcontrib><creatorcontrib>Borys, Dariusz, M.D</creatorcontrib><creatorcontrib>Canter, Robert J., M.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tseng, Warren, M.D</au><au>Martinez, Steve R., M.D., M.A.S</au><au>Tamurian, Robert M., M.D</au><au>Borys, Dariusz, M.D</au><au>Canter, Robert J., M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histologic Type Predicts Survival in Patients with Retroperitoneal Soft Tissue Sarcoma</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>2012</date><risdate>2012</risdate><volume>172</volume><issue>1</issue><spage>123</spage><epage>130</epage><pages>123-130</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><abstract>Background Histologic grade, completeness of resection, and presence of metastases are traditionally regarded as the primary factors in predicting survival for retroperitoneal soft tissue sarcoma (RPSTS). We sought to examine the importance of histologic type as a prognostic factor among patients with RPSTS. Methods We identified 2337 cases of RPSTS in the Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2004. After excluding 273 cases of age <18, identification by autopsy only, or absence of histologic confirmation, we arrived at a final study cohort of 2064 patients. Overall survival (OS) and disease-specific survival (DSS) were estimated using the Kaplan-Meier method. Multivariate analysis was performed using a Cox proportional hazards model, adjusting for age, gender, race, histologic type, histologic grade, tumor size, extent of resection, and SEER summary stage. Results Among 33 histologic types, leiomyosarcoma (28.7%), well-differentiated/dedifferentiated liposarcoma (20.3%), liposarcoma not otherwise specified (NOS) (11.9%), malignant fibrous histiocytoma (MFH–11.0%), and sarcoma NOS (10.7%) were the most prevalent. Grade distribution was low, 24.2%; intermediate, 16%; high 34.3%, and unknown, 25.5%. Surgery was performed in 85.8%, and radiotherapy was administered to 22.8%. With a median follow-up of 38 mo, median OS was 78, 35, 25, 18, and 10 mo for liposarcoma, leiomyosarcoma, other histologies, MFH, and sarcoma NOS, respectively ( P < 0.0001). Median DSS was 120, 53, not reached, 30, and 13 mo for liposarcoma, leiomyosarcoma, other histologies, MFH, and sarcoma NOS, respectively ( P < 0.0001). On multivariate analysis, histologic type was associated with statistically significant differences in both OS and DSS. Conclusions Histologic type is an important predictor of survival in RPSTS.</abstract><cop>United States</cop><pmid>20869082</pmid><doi>10.1016/j.jss.2010.07.056</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Female Histiocytoma, Malignant Fibrous - diagnosis Histiocytoma, Malignant Fibrous - mortality Histiocytoma, Malignant Fibrous - pathology Humans Kaplan-Meier Estimate Leiomyosarcoma - diagnosis Leiomyosarcoma - mortality Leiomyosarcoma - pathology Liposarcoma - diagnosis Liposarcoma - mortality Liposarcoma - pathology Male Middle Aged Multivariate Analysis Predictive Value of Tests Prognosis Retroperitoneal Neoplasms - diagnosis Retroperitoneal Neoplasms - mortality Retroperitoneal Neoplasms - pathology Retrospective Studies Sarcoma - diagnosis Sarcoma - mortality Sarcoma - pathology SEER Program Surgery Survival Rate United States |
| title | Histologic Type Predicts Survival in Patients with Retroperitoneal Soft Tissue Sarcoma |
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