Efficacy and Tolerability of Armodafinil: Effect on Clinical Condition Late in the Shift and Overall Functioning of Patients With Excessive Sleepiness Associated With Shift Work Disorder

• Published in: Journal of occupational and environmental medicine 2011-12, Vol.53 (12), p.1460-1465
• Main Authors: Erman, Milton K., Seiden, David J., Yang, Ronghua, Dammerman, Ryan
• Format: Article
• Language: English
• Subjects: Adult; Benzhydryl Compounds - adverse effects; Benzhydryl Compounds - therapeutic use; Biological and medical sciences; Central Nervous System Stimulants - adverse effects; Central Nervous System Stimulants - therapeutic use; Disorders of Excessive Somnolence - drug therapy; Double-Blind Method; Drug toxicity and drugs side effects treatment; Female; Humans; Male; Medical diagnosis; Medical sciences; Middle Aged; Miscellaneous (drug allergy, mutagens, teratogens...); ORIGINAL ARTICLES; Pharmacology. Drug treatments; Shift work; Sleep; Sleep Disorders, Circadian Rhythm - drug therapy; Studies; Wakefulness - drug effects; Young Adult
• ISSN: 1076-2752; 1536-5948
• DOI: 10.1097/JOM.0b013e318237a17e

Objective: This study examined the effect of armodafinil on late-in-shift clinical condition, wakefùlness, and overall functioning of patients with shift work disorder. Methods: Patients with clinically diagnosed shift work disorder received armodafinil or placebo on nights worked for 6 weeks. Patients included in the study experienced late-in-shift sleepiness between 4 AM and 8 AM (Karolinska Sleepiness Scale ≥6) and were functionally impaired (Global Assessment of Functioning