Efficacy and Tolerability of Armodafinil: Effect on Clinical Condition Late in the Shift and Overall Functioning of Patients With Excessive Sleepiness Associated With Shift Work Disorder

Objective: This study examined the effect of armodafinil on late-in-shift clinical condition, wakefùlness, and overall functioning of patients with shift work disorder. Methods: Patients with clinically diagnosed shift work disorder received armodafinil or placebo on nights worked for 6 weeks. Patie...

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Published in:Journal of occupational and environmental medicine 2011-12, Vol.53 (12), p.1460-1465
Main Authors: Erman, Milton K., Seiden, David J., Yang, Ronghua, Dammerman, Ryan
Format: Article
Language:English
Subjects:
Adult
Benzhydryl Compounds - adverse effects
Benzhydryl Compounds - therapeutic use
Biological and medical sciences
Central Nervous System Stimulants - adverse effects
Central Nervous System Stimulants - therapeutic use
Disorders of Excessive Somnolence - drug therapy
Double-Blind Method
Drug toxicity and drugs side effects treatment
Female
Humans
Male
Medical diagnosis
Medical sciences
Middle Aged
Miscellaneous (drug allergy, mutagens, teratogens...)
ORIGINAL ARTICLES
Pharmacology. Drug treatments
Shift work
Sleep
Sleep Disorders, Circadian Rhythm - drug therapy
Studies
Wakefulness - drug effects
Young Adult
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container_end_page 1465
container_issue 12
container_start_page 1460
container_title Journal of occupational and environmental medicine
container_volume 53
creator Erman, Milton K.
Seiden, David J.
Yang, Ronghua
Dammerman, Ryan
description Objective: This study examined the effect of armodafinil on late-in-shift clinical condition, wakefùlness, and overall functioning of patients with shift work disorder. Methods: Patients with clinically diagnosed shift work disorder received armodafinil or placebo on nights worked for 6 weeks. Patients included in the study experienced late-in-shift sleepiness between 4 AM and 8 AM (Karolinska Sleepiness Scale ≥6) and were functionally impaired (Global Assessment of Functioning
doi_str_mv 10.1097/JOM.0b013e318237a17e
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Methods: Patients with clinically diagnosed shift work disorder received armodafinil or placebo on nights worked for 6 weeks. Patients included in the study experienced late-in-shift sleepiness between 4 AM and 8 AM (Karolinska Sleepiness Scale ≥6) and were functionally impaired (Global Assessment of Functioning &lt;70). Efficacy was determined by improvements in clinical condition (Clinical Global Impression-Change), latein-the-shift Karolinska Sleepiness Scale score, and overall Global Assessment of Functioning score. Tolerability was assessed. Results: Patients receiving armodafinil showed significant improvements in late-in-shift clinical condition, wakefulness, and global functioning, compared to placebo at final visit. Armodafinil was generally well tolerated. Conclusions: Armodafinil improved clinical condition and wakefulness late in the night shift of patients with shift work disorder. Overall patient functioning was also improved.</description><identifier>ISSN: 1076-2752</identifier><identifier>EISSN: 1536-5948</identifier><identifier>DOI: 10.1097/JOM.0b013e318237a17e</identifier><identifier>PMID: 22104981</identifier><identifier>CODEN: JOEMFM</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams &amp; Wilkins</publisher><subject>Adult ; Benzhydryl Compounds - adverse effects ; Benzhydryl Compounds - therapeutic use ; Biological and medical sciences ; Central Nervous System Stimulants - adverse effects ; Central Nervous System Stimulants - therapeutic use ; Disorders of Excessive Somnolence - drug therapy ; Double-Blind Method ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; Male ; Medical diagnosis ; Medical sciences ; Middle Aged ; Miscellaneous (drug allergy, mutagens, teratogens...) ; ORIGINAL ARTICLES ; Pharmacology. 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Methods: Patients with clinically diagnosed shift work disorder received armodafinil or placebo on nights worked for 6 weeks. Patients included in the study experienced late-in-shift sleepiness between 4 AM and 8 AM (Karolinska Sleepiness Scale ≥6) and were functionally impaired (Global Assessment of Functioning &lt;70). Efficacy was determined by improvements in clinical condition (Clinical Global Impression-Change), latein-the-shift Karolinska Sleepiness Scale score, and overall Global Assessment of Functioning score. Tolerability was assessed. Results: Patients receiving armodafinil showed significant improvements in late-in-shift clinical condition, wakefulness, and global functioning, compared to placebo at final visit. Armodafinil was generally well tolerated. Conclusions: Armodafinil improved clinical condition and wakefulness late in the night shift of patients with shift work disorder. 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Methods: Patients with clinically diagnosed shift work disorder received armodafinil or placebo on nights worked for 6 weeks. Patients included in the study experienced late-in-shift sleepiness between 4 AM and 8 AM (Karolinska Sleepiness Scale ≥6) and were functionally impaired (Global Assessment of Functioning &lt;70). Efficacy was determined by improvements in clinical condition (Clinical Global Impression-Change), latein-the-shift Karolinska Sleepiness Scale score, and overall Global Assessment of Functioning score. Tolerability was assessed. Results: Patients receiving armodafinil showed significant improvements in late-in-shift clinical condition, wakefulness, and global functioning, compared to placebo at final visit. Armodafinil was generally well tolerated. Conclusions: Armodafinil improved clinical condition and wakefulness late in the night shift of patients with shift work disorder. 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identifier ISSN: 1076-2752
ispartof Journal of occupational and environmental medicine, 2011-12, Vol.53 (12), p.1460-1465
issn 1076-2752
1536-5948
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source JSTOR Archival Journals and Primary Sources Collection
subjects Adult
Benzhydryl Compounds - adverse effects
Benzhydryl Compounds - therapeutic use
Biological and medical sciences
Central Nervous System Stimulants - adverse effects
Central Nervous System Stimulants - therapeutic use
Disorders of Excessive Somnolence - drug therapy
Double-Blind Method
Drug toxicity and drugs side effects treatment
Female
Humans
Male
Medical diagnosis
Medical sciences
Middle Aged
Miscellaneous (drug allergy, mutagens, teratogens...)
ORIGINAL ARTICLES
Pharmacology. Drug treatments
Shift work
Sleep
Sleep Disorders, Circadian Rhythm - drug therapy
Studies
Wakefulness - drug effects
Young Adult
title Efficacy and Tolerability of Armodafinil: Effect on Clinical Condition Late in the Shift and Overall Functioning of Patients With Excessive Sleepiness Associated With Shift Work Disorder
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