Enantioselective Preparation of P-Chiral Phosphine Oxides

A highly efficient chiral auxiliary-based strategy for the asymmetric synthesis of P-chiral phosphine oxides in >98:2 er has been developed. The methodology involves the highly stereoselective formation of P-chiral oxazolidinones that then undergo displacement with a variety of Grignard reagents...

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Bibliographic Details
Published in:Organic letters 2011-12, Vol.13 (24), p.6576-6579
Main Authors: Adams, Harry, Collins, Rebecca C, Jones, Simon, Warner, Christopher J. A
Format: Article
Language:English
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Summary:A highly efficient chiral auxiliary-based strategy for the asymmetric synthesis of P-chiral phosphine oxides in >98:2 er has been developed. The methodology involves the highly stereoselective formation of P-chiral oxazolidinones that then undergo displacement with a variety of Grignard reagents to prepare the desired phosphine oxides.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol202916j