Multi-field-of-view SPECT is superior to whole-body scanning for assessing metastatic bone disease in patients with prostate cancer

• Published in: Tumori 2011-09, Vol.97 (5), p.629-633
• Main Authors: Giovanella, Luca, Castellani, Massimo, Suriano, Sergio, Ruberto, Teresa, Ceriani, Luca, Tagliabue, Luca, Lucignani, Giovanni
• Format: Article
• Language: English
• Subjects: Aged; Bone Neoplasms - diagnostic imaging; Bone Neoplasms - secondary; Humans; Male; Middle Aged; Predictive Value of Tests; Prostate-Specific Antigen - blood; Prostatic Neoplasms - blood; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - pathology; Radiopharmaceuticals; Sensitivity and Specificity; Technetium; Tomography, Emission-Computed, Single-Photon - methods; Whole Body Imaging - methods
• ISSN: 2038-2529
• DOI: 10.1700/989.10723

The aim of this study was to compare the diagnostic performance of whole-body bone scintigraphy (WBS) and multi-field-of-view single photon emission tomography (multi-FOV SPECT) with 99mTc-oxidronate (99mTc-HDP) in patients with prostate cancer (PCa). In a prospective study, WBS and SPECT acquisitions were performed in 194 patients with histologically confirmed PCa and serum prostate-specific antigen (PSA) levels above 10 ng/mL. Scans obtained using the two modalities were interpreted separately. Clinical and biochemical follow-up, radiological studies and biopsies served as benchmarks for the assessments. The impact of PSA level on WBS and SPECT results was also evaluated. The patient-based sensitivity, specificity, accuracy, PPV and NPV values of SPECT examinations were higher than those of WBS, especially in patients with serum PSA levels