Disseminated hypertrophic lichen planus: relevant response to acitretin

Hyperthrofic lichen planus is considered a variant of lichen planus with marked epidermal hyperplasia in response to persistent itch. It is clinically, characterized by symmetric hyperkeratotic plaques, of purplish-grey color, often located in the pretibial region. Intense pruritus, refractoriness t...

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Bibliographic Details
Published in:Anais brasileiros de dermatología 2011-07, Vol.86 (4 Suppl 1), p.S96-S99
Main Authors: Jaime, Thais Jerez, Jaime, Tatiana Jerez, Guaraldi, Bianca de Mello, Melo, Daniel Fernandes, Jeunon, Thiago, Lerer, Claudio
Format: Article
Language:eng ; por
Subjects:
Acitretin - therapeutic use
Female
Hand Dermatoses - drug therapy
Hand Dermatoses - pathology
Humans
Keratolytic Agents - therapeutic use
Lichen Planus - drug therapy
Lichen Planus - pathology
Middle Aged
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Summary:Hyperthrofic lichen planus is considered a variant of lichen planus with marked epidermal hyperplasia in response to persistent itch. It is clinically, characterized by symmetric hyperkeratotic plaques, of purplish-grey color, often located in the pretibial region. Intense pruritus, refractoriness to conventional treatments and the possibility of association of the long-term injuries with squamous cell carcinoma requires an effective treatment. The first-line treatment is corticosteroids which can be applied either topically or systemically. Other therapeutic modalities proposed are: NB-UVB phototherapy or PUVA, immunosuppressive drugs and systemic retinoids, notably acitretin. We report a case with exuberant clinical presentation of hyperthrofic lichen planus with excellent response to acitretin after nine months of treatment.
ISSN:1806-4841
DOI:10.1590/S0365-05962011000700025