The cerebellar cognitive profile

The cerebellar role in non-motor functions is supported by the clinical finding that lesions confined to cerebellum produce the cerebellar cognitive affective syndrome. Nevertheless, there is no consensus regarding the overall cerebellar contribution to cognition. Among other reasons, this deficienc...

Full description

Saved in:
Bibliographic Details
Published in:Brain (London, England : 1878) England : 1878), 2011-12, Vol.134 (12), p.3669-3683
Main Authors: Tedesco, Anna M., Chiricozzi, Francesca R., Clausi, Silvia, Lupo, Michela, Molinari, Marco, Leggio, Maria G.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Brain Mapping
Cerebellar Diseases - pathology
Cerebellar Diseases - physiopathology
Cerebellar Diseases - psychology
Cerebellum - injuries
Cerebellum - pathology
Cerebellum - physiopathology
Cognition - physiology
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Female
Humans
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurologic Examination
Neurology
Neuropsychological Tests
Retrospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The cerebellar role in non-motor functions is supported by the clinical finding that lesions confined to cerebellum produce the cerebellar cognitive affective syndrome. Nevertheless, there is no consensus regarding the overall cerebellar contribution to cognition. Among other reasons, this deficiency might be attributed to the small sample sizes and narrow breadths of existing studies on lesions in cerebellar patients, which have focused primarily on a single cognitive domain. The aim of this study was to examine the expression of cerebellar cognitive affective syndrome with regard to lesion topography in a large group of subjects with cerebellar damage. We retrospectively analysed charts from patients in the Ataxia Lab of Santa Lucia Foundation between 1997 and 2007. Of 223 charts, 156 were included in the study, focusing on the importance of the cerebellum in cognition and the relevance of lesion topography in defining the cognitive domains that have been affected. Vascular topography and the involvement of deep cerebellar nuclei were the chief factors that determined the cognitive profile. Of the various cognitive domains, the ability to sequence was the most adversely affected in nearly all subjects, supporting the hypothesis that sequencing is a basic cerebellar operation.
ISSN:0006-8950
1460-2156
DOI:10.1093/brain/awr266