Molecular diagnosis of lobomycosis-like disease in a bottlenose dolphin in captivity

We report the diagnosis and molecular characterization of lobomycosis-like lesions in a captive bottlenose dolphin. The clinical picture and the absence of growth in conventional media resembled the features associated with Lacazia loboi. However sequencing of ribosomal DNA and further phylogenetic...

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Bibliographic Details
Published in:Medical mycology (Oxford) 2012-01, Vol.50 (1), p.106-109
Main Authors: Esperón, Fernando, García-Párraga, Daniel, Bellière, Edwige Nina, Sánchez-Vizcaíno, José Manuel
Format: Article
Language:English
Subjects:
Animals
Animals, Zoo
Bottle-Nosed Dolphin
DNA, Fungal - chemistry
DNA, Fungal - genetics
Lobomycosis - pathology
Lobomycosis - veterinary
Molecular Sequence Data
Paracoccidioides - cytology
Paracoccidioides - genetics
Paracoccidioides - isolation & purification
Paracoccidioidomycosis - diagnosis
Paracoccidioidomycosis - microbiology
Paracoccidioidomycosis - pathology
Paracoccidioidomycosis - veterinary
Sequence Analysis, DNA
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Summary:We report the diagnosis and molecular characterization of lobomycosis-like lesions in a captive bottlenose dolphin. The clinical picture and the absence of growth in conventional media resembled the features associated with Lacazia loboi. However sequencing of ribosomal DNA and further phylogenetic analyses showed a novel sequence more related to Paracoccidioides brasilensis than to L. loboi. Moreover, the morphology of the yeast cells differed from those L. loboi causing infections humans. These facts suggest that the dolphin lobomycosis-like lesions might have been be caused by different a different fungus clustered inside the order Onygenales. A successful treatment protocol based on topic and systemic terbinafine is also detailed.
ISSN:1369-3786
1460-2709
DOI:10.3109/13693786.2011.594100