An overview of human protein databases and their application to functional proteomics in health and disease

Functional proteomics can be defined as a strategy to couple proteomic information with biochemical and physiological analyses with the aim of understanding better the functions of proteins in normal and diseased organs.In recent years,a variety of publicly available bioinformatics databases have be...

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Bibliographic Details
Published in:Science China. Life sciences 2011-11, Vol.54 (11), p.988-998
Main Authors: Zhang, YanQiong, Zhu, YunPing, He, FuChu
Format: Article
Language:English
Subjects:
Biochemistry
Bioinformatics
Biomedical and Life Sciences
Computational Biology - methods
Databases, Protein
Health
Human
Humans
Life Sciences
Proteins
Proteins - chemistry
Proteins - genetics
Proteins - metabolism
Proteomics
Proteomics - methods
Reviews
Strategy
人类蛋白质
健康
功能蛋白质组学
应用
生物信息学数据库
生理生化分析
疾病
蛋白质数据库
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Summary:Functional proteomics can be defined as a strategy to couple proteomic information with biochemical and physiological analyses with the aim of understanding better the functions of proteins in normal and diseased organs.In recent years,a variety of publicly available bioinformatics databases have been developed to support protein-related information management and biological knowledge discovery.In addition to being used to annotate the proteome,these resources also offer the opportunity to develop global approaches to the study of the functional role of proteins both in health and disease.Here,we present a comprehensive review of the major human protein bioinformatics databases.We conclude this review by discussing a few examples that illustrate the importance of these databases in functional proteomics research.
ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-011-4247-x