Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines

• Published in: Journal of ethnopharmacology 2012-01, Vol.139 (1), p.207-213
• Main Authors: Chen, Jinglou, Lei, Yongfang, Wu, Guanghua, Zhang, Yonghui, Fu, Wei, Xiong, Chaomei, Ruan, Jinlan
• Format: Article
• Language: English
• Subjects: Animals; Blood Glucose - analysis; Blood Urea Nitrogen; Creatinine - blood; Cytokines; Diet, High-Fat; Disease Models, Animal; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Edema; Ferns; Hyperlipidemia; Hyperlipidemias - drug therapy; Hyperlipidemias - etiology; Hyperlipidemias - metabolism; Inflammation; Kidney; Kidney - drug effects; Kidney - metabolism; Lipid Peroxidation - drug effects; Lipids - blood; Macrothelypteris; Macrothelypteris torresiana; Male; Metabolic disorders; Mice; Nephrotic syndrome; Nephrotic Syndrome - chemically induced; Nephrotic Syndrome - drug therapy; Nephrotic Syndrome - metabolism; Nitric oxide; Nitric Oxide - blood; Nitric Oxide Synthase Type II - blood; Oxidative stress; Oxidative Stress - drug effects; oxides; Phytotherapy; Polyphenols; Polyphenols - pharmacology; Polyphenols - therapeutic use; Potassium Dichromate; Protective Agents - pharmacology; Protective Agents - therapeutic use; puromycin; Puromycin Aminonucleoside; Urinary bladder; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - blood; Vascular Endothelial Growth Factor A - metabolism
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2011.11.002

Macrothelypteris torresiana is traditionally used in Chinese folk medicine for the treatment of edema for patients suffering from kidney/bladder problems due to its satisfactory therapeutic effectiveness. The aim of this study was to investigate the renoprotective nature of the total polyphenols fraction from Macrothelypteris torresiana (PMT). The biochemical criterions of plasma and kidney tissues were evaluated to study the effects of PMT on puromycin aminonucleoside-induced chronic nephrotic syndrome (NS) in hyperlipidemic mice. In this study, the NS and hyperlipidemia were ameliorated after 9 weeks administration of PMT. Besides, PMT was able to modulate the level of renal oxidative stress and vascular endothelial growth factor–nitric oxide (VEGF–NO) pathway. It represented a potential resource of PMT for the treatment of NS involved in metabolic syndrome.