Alternative Path to EMT: Regulation of Apicobasal Polarity in Drosophila

The epithelial-to-mesenchymal transition (EMT), a key process in morphogenesis, is often driven by repressing expression of adherens junction components, such as E-cadherin. In this issue of Developmental Cell, Campbell et al. (2011) uncover an alternative mechanism in the Drosophila embryonic gut t...

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Published in:Developmental cell 2011-12, Vol.21 (6), p.983-984
Main Authors: Lim, Jormay, Thiery, Jean Paul
Format: Article
Language:English
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Summary:The epithelial-to-mesenchymal transition (EMT), a key process in morphogenesis, is often driven by repressing expression of adherens junction components, such as E-cadherin. In this issue of Developmental Cell, Campbell et al. (2011) uncover an alternative mechanism in the Drosophila embryonic gut that promotes EMT via Serpent, a GATA transcriptional repressor of the apicobasal polarity gene crumbs.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2011.11.017