A simple parallel gas chromatography column screening system

A simple approach to the automated screening of four different columns on a single gas chromatography (GC) instrument is used for rapid chiral GC method development. Configuration of a conventional GC instrument with a second autosampler and several inexpensive Y‐splitters enables simultaneous evalu...

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Bibliographic Details
Published in:Chirality (New York, N.Y.) N.Y.), 2012-01, Vol.24 (1), p.1-4
Main Authors: Schafer, Wes, Hamilton, Simon E., Pirzada, Zainab, Welch, Christopher J.
Format: Article
Language:English
Subjects:
Chromatography, Gas - instrumentation
Chromatography, Gas - methods
fast analysis
method development
screening
Stereoisomerism
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Summary:A simple approach to the automated screening of four different columns on a single gas chromatography (GC) instrument is used for rapid chiral GC method development. Configuration of a conventional GC instrument with a second autosampler and several inexpensive Y‐splitters enables simultaneous evaluation of two different columns, allowing a total of four different columns to be evaluated in two automated back to back runs. The resulting system affords a simple and effective approach to chiral GC method development that speeds analysis while eliminating the need for slow and tedious manual interchange of columns. An example of developing a rapid isothermal GC method from the screening results obtained by the instrument is also shown. Chirality, 2011. © 2011 Wiley Periodicals, Inc.
ISSN:0899-0042
1520-636X
DOI:10.1002/chir.21974