Glycosphingolipids in signaling and development: From liposomes to model organisms

Since the launch of the raft hypothesis in 1997, data generated in liposomes and cultured cells have highlighted the role of glycosphingolipids (GSLs) in the dynamic organization of biological membranes and the activity of signaling complexes. In parallel studies, genetic analysis of the GSL synthet...

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Bibliographic Details
Published in:Developmental dynamics 2012-01, Vol.241 (1), p.92-106
Main Authors: Pontier, Stephanie M., Schweisguth, François
Format: Article
Language:English
Subjects:
Animals
Cell Membrane - chemistry
Cell Membrane - metabolism
development
EGFR
Endocytosis - physiology
glycosphingolipids
Glycosphingolipids - metabolism
Glycosyltransferases - metabolism
Liposomes - metabolism
Membrane Microdomains - metabolism
Membrane Proteins - genetics
Membrane Proteins - metabolism
Neurodegenerative Diseases - pathology
Neurodegenerative Diseases - physiopathology
Notch
Receptor, Epidermal Growth Factor - metabolism
Receptors, Notch - metabolism
Signal Transduction - physiology
signaling
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Summary:Since the launch of the raft hypothesis in 1997, data generated in liposomes and cultured cells have highlighted the role of glycosphingolipids (GSLs) in the dynamic organization of biological membranes and the activity of signaling complexes. In parallel studies, genetic analysis of the GSL synthetic pathway has begun to reveal some of the specific roles of GSLs in vivo. Here, we review the role of GSLs in signaling in the context of a refined raft hypothesis. Recent genetic studies in worms, flies, and mice give us the opportunity to integrate these in vivo data with earlier in vitro liposome studies. Developmental Dynamics 241:92–106, 2012. © 2011 Wiley Periodicals, Inc.
ISSN:1058-8388
1097-0177
DOI:10.1002/dvdy.22766