Dermal dendritic cells in psoriasis, nummular dermatitis, and normal-appearing skin

Background The reason psoriasis (PSO) favors extensor skin is unknown. We hypothesized that PSO may involve extensor skin preferentially because of differences in the number or type of dermal dendritic cells (dDCs) between flexural and extensor skin. Objective We sought to compare dDC type and distr...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2012-01, Vol.66 (1), p.98-105
Main Authors: Clarke, Loren E., MD, Helm, Klaus F., MD, Hennessy, Jeannie, MD, Bruggeman, Richard D., MS, Clarke, Jennie T., MD
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
CD11
CD123
CD207
CD303
dendritic cells
Dermatitis - complications
Dermatitis - metabolism
Dermatitis - pathology
Dermatology
Humans
Immunohistochemistry
Langerhans Cells - pathology
Medical sciences
Middle Aged
psoriasis
Psoriasis - metabolism
Psoriasis - pathology
Psoriasis. Parapsoriasis. Lichen
Skin - pathology
Skin involvement in other diseases. Miscellaneous. General aspects
Young Adult
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Summary:Background The reason psoriasis (PSO) favors extensor skin is unknown. We hypothesized that PSO may involve extensor skin preferentially because of differences in the number or type of dermal dendritic cells (dDCs) between flexural and extensor skin. Objective We sought to compare dDC type and distribution in normal-appearing flexural and extensor skin, PSO, and nummular dermatitis (ND). Methods Using immunohistochemical markers, the number, distribution, and type of Langerhans cells, myeloid dendritic cells (DCs), and plasmacytoid DCs was compared in normal-appearing skin, PSO, and ND. Results Significant differences in dDC density were not identified between flexural and extensor skin, although extensor skin contained fewer CD11a+ and CD11c+ cells. Compared with normal-appearing skin, cells expressing CD11a, CD11c, CD123, CD303, and CD207 were increased in PSO. ND lesions showed similar increases. No significant difference between PSO and ND was evident with the exception of decreased S100A6+ cells in PSO. Limitations We did not study seasonal variation in DC density or assess nonlesional skin from patients with PSO. Conclusions The data did not support the hypothesis that PSO favors extensor skin because of differences in DC localization. However, dDCs were significantly increased in PSO by comparison with normal-appearing skin, supporting existing evidence that they are involved in the overall pathogenesis of PSO.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2010.12.001