SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population

The transient receptor potential (TRP) superfamily of non‐selective cationic channels are involved in several processes plausibly relevant to migraine pathophysiology, including multimodal sensory and pain perception, central and peripheral sensitization, and regulation of calcium homeostasis. With...

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Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2012-01, Vol.159B (1), p.94-103
Main Authors: Carreño, Oriel, Corominas, Roser, Fernández-Morales, Jessica, Camiña, Montserrat, Sobrido, María-Jesús, Fernández-Fernández, José Manuel, Pozo-Rosich, Patricia, Cormand, Bru, Macaya, Alfons
Format: Article
Language:English
Subjects:
Adult
association study
Biological and medical sciences
Calcium homeostasis
Capsaicin receptors
Case-Control Studies
Female
Genetic Association Studies
Genetic Markers
Genetic Predisposition to Disease
Genetics
Haplotypes
Headache
Homeostasis
Humans
Linkage Disequilibrium - genetics
Male
Medical genetics
Medical sciences
Migraine
Migraine Disorders - genetics
Migraine with Aura - genetics
Neurology
Pain perception
Polymorphism, Single Nucleotide - genetics
Replication
Reproducibility of Results
Single-nucleotide polymorphism
Software
Spain
Transient receptor potential proteins
TRP
TRPM Cation Channels - genetics
TRPV Cation Channels - genetics
vanilloid
Vascular diseases and vascular malformations of the nervous system
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Summary:The transient receptor potential (TRP) superfamily of non‐selective cationic channels are involved in several processes plausibly relevant to migraine pathophysiology, including multimodal sensory and pain perception, central and peripheral sensitization, and regulation of calcium homeostasis. With the aim of identifying single nucleotide polymorphisms (SNPs) in TRP genes that may confer increased genetic susceptibility to migraine, we carried out a case–control genetic association study with replication, including a total of 1,040 cases and 1,037 controls. We genotyped 149 SNPs covering 14 TRP genes with known brain expression. The two‐stage study comprised samples of 555 and 485 Spanish, Caucasian patients, selected according to the ICHD‐II criteria for the diagnosis of migraine without aura (MO) or migraine with aura (MA). In the discovery sample, 19 SNPs in ten TRP genes showed nominal association (P 
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.32007