Combination of Microdermabrasion and 5‐Fluorouracil to Induce Repigmentation in Vitiligo: An Observational Study

BACKGROUND Treatment of resistant vitiligo is challenging. A few well‐researched studies have shown variable results with surgical and other therapeutic strategies. OBJECTIVE To evaluate the usefulness of a less‐painful method of repigmentation of vitiligo patches. PATIENTS AND METHODS Forty vitilig...

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Bibliographic Details
Published in:Dermatologic surgery 2011-12, Vol.37 (12), p.1763-1766
Main Authors: GARG, TARU, CHANDER, RAM, JAIN, ARPITA
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Child
Combined Modality Therapy
Dermabrasion
Dermatology
Female
Fluorouracil - administration & dosage
Humans
India
Male
Medical sciences
Middle Aged
Pigmentary diseases of the skin
Skin Pigmentation - drug effects
Skin plastic surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Vitiligo - pathology
Vitiligo - therapy
Young Adult
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Summary:BACKGROUND Treatment of resistant vitiligo is challenging. A few well‐researched studies have shown variable results with surgical and other therapeutic strategies. OBJECTIVE To evaluate the usefulness of a less‐painful method of repigmentation of vitiligo patches. PATIENTS AND METHODS Forty vitiligo patches in 22 consecutive patients with resistant vitiligo presenting at a vitiligo clinic of a university teaching medical school in New Delhi, India, were treated with microdermabrasion followed by topical 5% 5‐fluorouracil (5‐FU). RESULTS  One‐third of the patches showed more than 50% repigmentation, and one‐fourth showed more than 75% repigmentation. Gratifying results were obtained in seven patches after a single session. CONCLUSION Microdermabrasion is adjunctive with topical 5% 5‐FU in the treatment of resistant vitiligo patches. Further well‐controlled randomized trials are required to validate the observations of the study. The authors have indicated no significant interest with commercial supporters.
ISSN:1076-0512
1524-4725
DOI:10.1111/j.1524-4725.2011.02127.x