Correlation of clinical performance with ‘in vitro tests’ of restorative dental materials that use polymer-based matrices

Abstract Objective Review correlations of in vivo clinical performance with in vitro laboratory tests of restorative dental materials involving polymer-based matrices. Identify those factors interfering with the process. Materials and methods An evidence-based dentistry approach was used to identify...

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Bibliographic Details
Published in:Dental materials 2012-01, Vol.28 (1), p.52-71
Main Author: Bayne, Stephen C
Format: Article
Language:English
Subjects:
Advanced Basic Science
Clinical properties
Clinical trials
Clinical Trials as Topic
Correlation
Dental Bonding
Dental Leakage
Dental materials
Dental Materials - chemistry
Dental Materials - standards
Dental Research - methods
Dental Restoration Failure
Dental Restoration Wear
Dental Restoration, Permanent - standards
Dental Stress Analysis - methods
Dental Stress Analysis - standards
Dentistry
Evidence-Based Dentistry
Humans
In vitro testing
Laboratory properties
Materials Testing - methods
Materials Testing - standards
Mathematical analysis
Matrices
Matrix methods
Mechanical Phenomena
Meta-Analysis as Topic
Outcome Assessment (Health Care)
Polymers - chemistry
Research Design - standards
Restoration
Review Literature as Topic
Structure-Activity Relationship
Texture
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Summary:Abstract Objective Review correlations of in vivo clinical performance with in vitro laboratory tests of restorative dental materials involving polymer-based matrices. Identify those factors interfering with the process. Materials and methods An evidence-based dentistry approach was used to identify clinical trials, critical reviews, and meta-analyses involving correlations. Factors impacting meaningful correlations were reviewed. The limited bona fide correlations were reviewed. Results In vitro tests include physical, chemical, mechanical, and biological properties. Clinical research measurements routinely include 10–15 categories of clinical observations of performance such as color match, caries resistance, marginal integrity, surface texture, and others, but do not correspond well with laboratory properties. Clinical trials of restorative dental materials represent a small fraction of the total research in this arena (typically
ISSN:0109-5641
1879-0097
DOI:10.1016/j.dental.2011.08.594