Clinical and EEG features of acute intrathecal baclofen overdose

[...]we estimated that the patient received 55mg baclofen intrathecally. The hypothesis is that blocking the presynaptic release of neurotransmitters would lead to a suppression of inhibition, through an effect on inhibitory interneurons, resulting in cellular polarization responsible for seizures [...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2012-01, Vol.114 (1), p.84-86
Main Authors: Sauneuf, Bertrand, Totouom, Hervé Kamga, Savary, Benoit, Varin, Laurent, Dupeyrat, Julien, Ramakers, Sophie, Hanouz, Jean-Luc
Format: Article
Language:English
Subjects:
Acute respiratory failure
Baclofen
Baclofen - administration & dosage
Baclofen - adverse effects
Baclofen - cerebrospinal fluid
Biological and medical sciences
Drug Overdose
Drug therapy
Electroencephalography
Electroencephalography - drug effects
Ependymoma - surgery
Equipment Failure
GABA Agonists - administration & dosage
GABA Agonists - adverse effects
GABA Agonists - cerebrospinal fluid
Glasgow Coma Scale
Humans
Implantable pump
Infusion Pumps, Implantable
Injections, Spinal
Intensive care
Intrathecal overdose
Male
Medical sciences
Middle Aged
Muscle Relaxants, Central - administration & dosage
Muscle Relaxants, Central - adverse effects
Muscle Relaxants, Central - cerebrospinal fluid
Neurology
Neurosurgery
Quadriplegia - etiology
Respiratory Distress Syndrome, Adult - etiology
Spinal Neoplasms - surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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Summary:[...]we estimated that the patient received 55mg baclofen intrathecally. The hypothesis is that blocking the presynaptic release of neurotransmitters would lead to a suppression of inhibition, through an effect on inhibitory interneurons, resulting in cellular polarization responsible for seizures [10]. [...]while baclofen may have antiepileptic properties at low doses, high doses lead to a net excitatory effect.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2011.07.028