Aortic dissecting aneurysms—Histopathological findings

Abstract Acute aortic dissection is a life-threatening disease with a high rate of mortality. At the Institute of Legal Medicine of the Hanover Medical School, 30 cases with aortic dissections were found during autopsy and examined histologically between 2006 and 2009. The grade of medial alteration...

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Bibliographic Details
Published in:Forensic science international 2012-01, Vol.214 (1), p.13-17
Main Authors: Bode-Jänisch, S, Schmidt, A, Günther, D, Stuhrmann, M, Fieguth, A
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging
Aging - pathology
Aneurysm, Dissecting - pathology
Aneurysms
Aorta
Aorta - metabolism
Aorta - pathology
Aortic Aneurysm - pathology
Aortic dissecting aneurysm
Arteriosclerosis - pathology
Autopsies
Autopsy
Biological and medical sciences
Case-Control Studies
Cystic medial necrosis
Dissection
Elastin
Elastin - metabolism
Female
Fibrosis
Forensic medicine
Forensic Pathology
Forensic science
Forensic sciences
Fragmentation
Gangrene
General aspects
Genetic disorders
Heart attacks
Hereditary disease
Humans
Hypertension
Investigative techniques, diagnostic techniques (general aspects)
Legal medicine
Male
Marfan syndrome
Medial changes
Medical sciences
Middle Aged
Mortality
Necrosis
Pathology
Public health. Hygiene
Public health. Hygiene-occupational medicine
Samples
Tunica Media - pathology
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Summary:Abstract Acute aortic dissection is a life-threatening disease with a high rate of mortality. At the Institute of Legal Medicine of the Hanover Medical School, 30 cases with aortic dissections were found during autopsy and examined histologically between 2006 and 2009. The grade of medial alterations in the form of cystic medial necrosis, elastin fragmentation, fibrosis and medionecrosis were estimated semi-quantitatively. In order to assess the normal aging process, samples of the aortic wall of 25 decedents without dissecting aneurysms were analyzed histologically. This study demonstrates that there are partly quantitative differences, particularly with a statistically significant increase in cystic medial necrosis ( p < 0.001) and elastin fragmentation ( p < 0.001), between aortas from dissecting aneurysms and the normal aging aorta, which may help to identify genetically predisposed relatives of patients with a dissection of the aorta.
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2011.07.006