Serum 25-hydroxyvitamin D concentration and arterial stiffness among type 2 diabetes

Abstract Aim To evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] and arterial stiffness in patients with type 2 diabetes. Methods Serum 25(OH)D was measured in a cross-sectional sample of 131 men and 174 women aged 30 years and over in Korea. Arterial stiffness was assessed by pu...

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Published in:Diabetes research and clinical practice 2012-01, Vol.95 (1), p.42-47
Main Authors: Lee, Jee-In, Oh, Su-Jin, Ha, Won-Chul, Kwon, Hyuk-Sang, Sohn, Tae-Seo, Son, Hyun-Shik, Cha, Bong-Yun
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Adult
Aged
Arterial stiffness
Brachial Artery - physiopathology
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Endocrinology & Metabolism
Female
Humans
Male
Middle Aged
Republic of Korea
Type 2 diabetes
Vascular Stiffness - physiology
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - physiopathology
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Summary:Abstract Aim To evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] and arterial stiffness in patients with type 2 diabetes. Methods Serum 25(OH)D was measured in a cross-sectional sample of 131 men and 174 women aged 30 years and over in Korea. Arterial stiffness was assessed by pulse wave velocity (PWV) obtained with a VP-2000 pulse wave unit. Fasting plasma glucose, insulin, lipid profile, HbA1c, calcium, phosphorous, and HS-CRP were measured. Results The prevalence of vitamin D deficiency was high (85.9%). Those with lower vitamin D levels had increased PWV. Using multivariate regression analysis, low 25(OH)D concentrations independently predicted PWV ( p < 0.001) in people with type 2 diabetes after adjustment for other risk factors such as age, smoking, hypertension, HS-CRP, diabetes duration, hypertension duration, HbA1c, and BMI. Conclusions Vitamin D deficiency is common in type 2 diabetes, and a low 25(OH)D level is significantly associated with increased arterial stiffness in these patients. Vitamin D may influence the development of cardiovascular disease. Clinical intervention studies are needed to clarify whether treatment with vitamin D decreases the risk of cardiovascular disease in patients with type 2 diabetes.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2011.09.006