Common variation in oxidative phosphorylation genes is not a major cause of insulin resistance or type 2 diabetes

Aims/hypothesis There is substantial evidence that mitochondrial dysfunction is linked to insulin resistance and is present in several tissues relevant to the pathogenesis of type 2 diabetes. Here, we examined whether common variation in genes involved in oxidative phosphorylation (OxPhos) contribut...

Full description

Saved in:
Bibliographic Details
Published in:Diabetologia 2012-02, Vol.55 (2), p.340-348
Main Authors: Snogdal, L. S., Wod, M., Grarup, N., Vestmar, M., Sparsø, T., Jørgensen, T., Lauritzen, T., Beck-Nielsen, H., Henriksen, J. E., Pedersen, O., Hansen, T., Højlund, K.
Format: Article
Language:English
Subjects:
Alleles
Biological and medical sciences
Body fat
Case-Control Studies
Denmark
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - metabolism
Diabetes. Impaired glucose tolerance
Electron Transport Complex IV - genetics
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Genetic Variation
Genomes
Glucose
Glucose - metabolism
Health sciences
Human Physiology
Humans
Hypotheses
Influence
Insulin Resistance
Internal Medicine
Medical sciences
Medicine
Medicine & Public Health
Meta-analysis
Metabolic Diseases
Metabolism
Metabolites
Mitochondria - metabolism
Models, Biological
Models, Genetic
Musculoskeletal system
Oxidative Phosphorylation
Oxygen - chemistry
Pathogenesis
Phosphorylation
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims/hypothesis There is substantial evidence that mitochondrial dysfunction is linked to insulin resistance and is present in several tissues relevant to the pathogenesis of type 2 diabetes. Here, we examined whether common variation in genes involved in oxidative phosphorylation (OxPhos) contributes to type 2 diabetes susceptibility or influences diabetes-related metabolic traits. Methods OxPhos gene variants ( n  = 10) that had been nominally associated ( p  
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-011-2377-0