The NMDA receptor complex as a therapeutic target in epilepsy: a review

Abstract A substantial amount of research has shown that N -methyl-D-aspartate receptors (NMDARs) may play a key role in the pathophysiology of several neurological diseases, including epilepsy. Animal models of epilepsy and clinical studies demonstrate that NMDAR activity and expression can be alte...

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Bibliographic Details
Published in:Epilepsy & behavior 2011-12, Vol.22 (4), p.617-640
Main Authors: Ghasemi, Mehdi, Schachter, Steven C
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Epilepsy
Epilepsy - drug therapy
Epilepsy - metabolism
Excitatory Amino Acid Antagonists - therapeutic use
Humans
Neurology
NMDA receptor
NMDA receptor antagonist
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate - metabolism
Seizure
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Summary:Abstract A substantial amount of research has shown that N -methyl-D-aspartate receptors (NMDARs) may play a key role in the pathophysiology of several neurological diseases, including epilepsy. Animal models of epilepsy and clinical studies demonstrate that NMDAR activity and expression can be altered in association with epilepsy and particularly in some specific seizure types. NMDAR antagonists have been shown to have antiepileptic effects in both clinical and preclinical studies. There is some evidence that conventional antiepileptic drugs may also affect NMDAR function. In this review, we describe the evidence for the involvement of NMDARs in the pathophysiology of epilepsy and provide an overview of NMDAR antagonists that have been investigated in clinical trials and animal models of epilepsy.
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2011.07.024