Investigation of a large community-based outbreak of hepatitis B infection in the United Kingdom

We describe the largest outbreak of hepatitis B virus infection reported to date in the UK. Between July 2001 and December 2005, 237 cases were identified in Avon, South West England. The likely route of transmission was injecting drug use in 44% (104/237) and heterosexual intercourse in 30% (71/237...

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Bibliographic Details
Published in:Epidemiology and infection 2012-01, Vol.140 (1), p.47-57
Main Authors: ANDERSSON, M. I., LOW, N., IRISH, C. J., VERLANDER, N. Q., CARRINGTON, D., HORNER, P., STUART, J. M., HICKMAN, M.
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Antibodies
Antigens
Biological and medical sciences
Case-Control Studies
Community-Acquired Infections - epidemiology
Community-Acquired Infections - transmission
Community-Acquired Infections - virology
Disease Outbreaks
Drug use
Drug Users - statistics & numerical data
England - epidemiology
Female
Fundamental and applied biological sciences. Psychology
Hepatitis
Hepatitis antigens
Hepatitis B
Hepatitis B - epidemiology
Hepatitis B - transmission
Hepatitis B virus
Human viral diseases
Humans
Hypotheses
Immunization
Infections
Infectious diseases
Injections
Investigations
Laboratories
Male
Medical sciences
Medical syringes
Men
Microbiology
Middle Aged
Multivariate Analysis
Predisposing factors
Public health
Questionnaires
Risk Factors
Risk-Taking
Vaccination
Vaccines
Viral diseases
Viral hepatitis
Virology
Viruses
Workers
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Summary:We describe the largest outbreak of hepatitis B virus infection reported to date in the UK. Between July 2001 and December 2005, 237 cases were identified in Avon, South West England. The likely route of transmission was injecting drug use in 44% (104/237) and heterosexual intercourse in 30% (71/237) of cases. A case-control study in injectors showed that injecting crack cocaine [adjusted odds ratio (aOR) 23·8, 95% confidence interval (CI) 3·04–186, P
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268811000148