Preparation of polyion complex micelles from poly(ethylene glycol)- block-polyions

Polyion complex micelles (PICMs) arise from the spontaneous self-assembly of ionic polymers of opposite charges to form a condensate that is dispersed in aqueous media by a hydrophilic segment, usually poly(ethylene glycol) (PEG), present on at least one of the two ionic polymers. PICMs are used for...

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Bibliographic Details
Published in:Journal of controlled release 2011-12, Vol.156 (2), p.118-127
Main Authors: Bayó-Puxan, Núria, Dufresne, Marie-Hélène, Felber, Arnaud E., Castagner, Bastien, Leroux, Jean-Christophe
Format: Article
Language:English
Subjects:
Atom transfer radical polymerization (ATRP)
Biological and medical sciences
composite polymers
Drug Carriers - chemistry
drugs
General pharmacology
hydrophilicity
Hydrophobic and Hydrophilic Interactions
Ions - chemistry
Medical sciences
Micelles
Nucleic acid
nucleic acids
Nucleic Acids - administration & dosage
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyanion
Polycation
Polyethylene Glycols - chemistry
Polyion complex micelle (PICM)
Polymeric micelle
Polymerization
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Summary:Polyion complex micelles (PICMs) arise from the spontaneous self-assembly of ionic polymers of opposite charges to form a condensate that is dispersed in aqueous media by a hydrophilic segment, usually poly(ethylene glycol) (PEG), present on at least one of the two ionic polymers. PICMs are used for many applications, especially drug delivery. This protocol paper describes the preparation by atom transfer radical polymerization (ATRP) of diblock copolymers of PEG bearing either positive or negative charges, both of which have been shown to form PICMs. Furthermore, methods of preparation and characterization of PICMs loaded with nucleic acid drugs are presented. [Display omitted]
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2011.07.027