Pre-clinical toxicity of Morinda citrifolia Linn. leaf extract

This investigation was carried out to evaluate the safety of an aqueous extract of Morinda citiifolia leaves (AEMC) by determining its potential toxicity after acute administration (5 g/kg) in rodents and cytotoxic studies. General behavior adverse effects and mortality were determined for up to 14...

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Bibliographic Details
Published in:African journal of biotechnology 2011-10, Vol.10 (65), p.14566-14572
Main Authors: Serafini, M R, de Lima, CM, Santos, R C, Doria, GAA, de Jesus, JY, de Melo, MGD, dos Santos, JPA, Rabelo, T K, tes, V S, Fonseca, MJV, de Albuquerque, RLC, Quintans-Junior, L J, de Souza Araujo, AA
Format: Article
Language:English
Subjects:
Morinda citrifolia
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Summary:This investigation was carried out to evaluate the safety of an aqueous extract of Morinda citiifolia leaves (AEMC) by determining its potential toxicity after acute administration (5 g/kg) in rodents and cytotoxic studies. General behavior adverse effects and mortality were determined for up to 14 days. Biochemical and hematological parameters were determined after 14 days. Cytotoxic effects of the AEMC were determined by spectrophotometric 3-(4, 5-dimethylthiazole-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay (at concentration of 0.05 to 25 mg/ml). The results showed that in the acute study in rats, the AEMC did not cause general behavior adverse effects and mortality. Also, AEMC did not show any cytotoxic effect at 0.05 to 12.5 mg/ml, only at 25 mg/ml. The AEMC does not appear to have significant toxicity.
ISSN:1684-5315
1684-5315