Changing pattern of antibiotic susceptibility in intensive care units: Ten years experience of a university hospital

• Published in: Anaerobe 2011-12, Vol.17 (6), p.422-425
• Main Authors: Alp, Emine, Kiran, Bilge, Altun, Dilek, Kalin, Gamze, Coskun, Ramazan, Sungur, Murat, Akin, Aynur, Percin, Duygu, Doganay, Mehmet
• Format: Article
• Language: English
• Subjects: Acinetobacter baumannii; Anti-Bacterial Agents - pharmacology; Antibiotic resistance; Bacteria - classification; Bacteria - drug effects; Bacteria - isolation & purification; Bacterial Infections - epidemiology; Bacterial Infections - microbiology; carbapenems; ciprofloxacin; control methods; Cross Infection - epidemiology; Cross Infection - microbiology; disease control; Drug Resistance, Bacterial; Escherichia coli; hospitals; Hospitals, University; Humans; Incidence; Infection control; Intensive care unit; Intensive Care Units; issues and policy; Klebsiella pneumoniae; Microbial Sensitivity Tests; microorganisms; monitoring; Pseudomonas; Retrospective Studies; Staphylococcus aureus
• ISSN: 1075-9964; 1095-8274
• DOI: 10.1016/j.anaerobe.2011.04.017

The study was performed to assess microorganisms and antibiotic susceptibility patterns during ten years in intensive care units of a University Hospital. Infection Control Committee has active, prospective surveillance in ICUs for thirteen years. Ten years data of ICUs was evaluated retrospectively from surveillance forms. Microorganisms and their antibiotic resistance were recorded according to the years. During ten years, gram negative microorganisms were the most frequent isolated microorganisms from clinical specimens. Acinetobacter baumannii (21.8%), Pseudomonas aerigunosa (16%), Escherichia coli (10.4%) and Klebsiella pneumoniae (8%) were the most common gram negative microorganisms. However, Staphylococcus aureus was the most prevalent gram positive microorganism, the incidence decreased from 18.6% to 4.8% during ten years. Also antibiotic susceptibility of microorganisms changed during ten years. Carbapenem resistance increased from 44% to 92% in A. baumannii and ciprofloxacin resistance increased in E. coli from 28% to 60% and in K. pneumoniae from 21% to 55% during ten years. However, methicilin resistance decreased in S. aureus from 96% to 54%. In conclusion, antibiotic resistance is growing problem in ICUs. Rationale antibiotic policies and infection control measures will prevent the development of resistance.