PAPP-A levels of late pregnancy in preeclampsia and HELLP syndrome

Purpose To determine the relationship between pregnancy-associated plasma protein-A (PAPP-A) levels and preeclampsia and HELLP syndrome at last trimester and to investigate if the severity of preeclampsia would be associated with PAPP-A levels. Methods Four groups were constructed; mild-preeclampsia...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2012, Vol.285 (1), p.45-49
Main Authors: Atis, Alev, Aydin, Yavuz, Basol, Elif, Kaleli, Semih, Turgay, Fatma, Goker, Nimet
Format: Article
Language:English
Subjects:
Adult
Endocrinology
Female
Gestational Age
Gynecology
Health risk assessment
HELLP Syndrome - blood
HELLP Syndrome - diagnosis
Human Genetics
Humans
Materno-Fetal Medicine
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Pre-Eclampsia - blood
Pre-Eclampsia - diagnosis
Predictive Value of Tests
Preeclampsia
Pregnancy
Pregnancy Outcome
Pregnancy Trimester, Third
Pregnancy-Associated Plasma Protein-A - analysis
Prospective Studies
Severity of Illness Index
Young Adult
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Summary:Purpose To determine the relationship between pregnancy-associated plasma protein-A (PAPP-A) levels and preeclampsia and HELLP syndrome at last trimester and to investigate if the severity of preeclampsia would be associated with PAPP-A levels. Methods Four groups were constructed; mild-preeclampsia group consisted of 19 women, severe-preeclampsia group 17, HELLP group 5 and control group 32 women. All groups were matched strictly for gestational age at last trimester. Maternal blood samples for PAPP-A were collected as soon as the patients were diagnosed as preeclampsia or HELLP syndrome at last trimester and compared. Results Mean ages of participants, parity, gestational week, and fetal weights were similar. Mean PAPP-A levels were significantly higher in preeclampsia and HELLP groups compared to control group. PAPP-A levels were not different among mild-severe preeclampsia and HELLP groups. There was significant, positive and strong correlation between gestational age and PAPP-A level and also between fetal weight and PAPP-A levels (correlation coefficents = 0.83 and 0.78 respectively). Conclusion PAPP-A level at last trimester increases in all mild-severe preeclampsia and HELLP syndrome, but is not predictive for severity of preeclampsia or HELLP syndrome.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-011-1912-z