Systemic inflammation and antibodies to citrullinated peptides in hand osteoarthritis

To investigate systemic inflammation and autoimmune response to citrullinated peptides in patients with erosive and non erosive 'lone' hand osteoarthritis (HOA) with no hip/knee involvement and their relationship with radiographic structural damage. Sera were obtained from a total of 99 pa...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental rheumatology 2011-11, Vol.29 (6), p.1006-1009
Main Authors: DOLZANI, P, ASSIRELLI, E, PULSATELLI, L, ADDIMANDA, O, MANCARELLA, L, PERI, G, MANTOVANI, A, FACCHINI, A, MELICONI, R
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Autoimmunity
Biological and medical sciences
Biomarkers - blood
C-Reactive Protein - analysis
Diseases of the osteoarticular system
Female
Hand Joints - diagnostic imaging
Hand Joints - pathology
Humans
Inflammation - blood
Inflammation - diagnostic imaging
Inflammation - pathology
Interleukin-6 - blood
Male
Medical sciences
Middle Aged
Miscellaneous. Osteoarticular involvement in other diseases
Osteoarthritis
Osteoarthritis - blood
Osteoarthritis - diagnosis
Osteoarthritis - diagnostic imaging
Peptides, Cyclic - immunology
Radiography
Serum Amyloid P-Component - analysis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate systemic inflammation and autoimmune response to citrullinated peptides in patients with erosive and non erosive 'lone' hand osteoarthritis (HOA) with no hip/knee involvement and their relationship with radiographic structural damage. Sera were obtained from a total of 99 patients with HOA (52 patients with erosive HOA and 47 patients with non-erosive HOA) and from 50 control subjects (NC). Hand radiographs were obtained from all patients and scored for joint damage according to the Kellgren-Lawrence and the Kallman scores. Serum levels of high-sensitivity CRP (hsCRP), IL-6, pentraxin-3 (PTX-3), anti-CCP and anti-modified citrullinated vimentin (MCV) antibodies were evaluated by a sandwich ELISA. Circulating levels of inflammatory biomarkers hsCRP, IL-6 and PTX3 were not significantly different in the two groups of patients with erosive and non-erosive HOA compared to NC and no significant difference was seen between non-erosive and erosive HOA. Anti-CCP positivity was detected respectively in 1 patient (2.1%) with non-erosive HOA and 1 patient (1.9%) with erosive HOA. Anti-MCV antibodies were present in 4 patients (8.5%) with non-erosive HOA, and 4 patients (7.7%) with erosive HOA. In the control group, one subject (2%) was positive for anti-CCP and 2 subjects (4%) had anti-MCV antibodies. Significant correlation was obtained only between body mass index and hsCRP concentration (r=0.4071; p
ISSN:0392-856X
1593-098X