Cancer in pregnancy. Part I: basic diagnostic and therapeutic principles and treatment of gynecological malignancies

Purpose Cancer in pregnancy is a rare circumstance. However, the coincidence of pregnancy and malignancy is supposed to increase due to a general tendency of postponing childbearing to older age. To date, clinical guidelines are scarce and experience regarding therapeutic management is limited to ca...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2012, Vol.285 (1), p.195-205
Main Authors: Hoellen, Friederike, Reibke, Roland, Hornemann, Katrin, Thill, Marc, Luedders, Doerte W., Kelling, Katharina, Hornemann, Amadeus, Bohlmann, Michael K.
Format: Article
Language:English
Subjects:
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Cancer
Endocrinology
Female
Genital Neoplasms, Female - diagnosis
Genital Neoplasms, Female - therapy
Gynecologic Oncology
Gynecology
Human Genetics
Humans
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Pregnancy
Pregnancy Complications, Neoplastic - diagnosis
Pregnancy Complications, Neoplastic - therapy
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Summary:Purpose Cancer in pregnancy is a rare circumstance. However, the coincidence of pregnancy and malignancy is supposed to increase due to a general tendency of postponing childbearing to older age. To date, clinical guidelines are scarce and experience regarding therapeutic management is limited to case reports. Methods This review focuses on general diagnostic and therapeutic principles including systemic therapy for malignancies in pregnancy. Results In part I, we report on diagnosis and therapy of gynecological tumors. Conclusion The diagnosis of gestational cancer faces both oncologist and obstetrician to the dilemma of applying appropriate diagnostic techniques and adequate local and systemic therapy to an expectant mother without harming the fetus.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-011-2058-8