Pentoxifylline and tocopherol in the management of patients with osteoradionecrosis, the Portsmouth experience

Abstract Osteoradionecrosis of the jaw remains the most problematic consequence of radiotherapy for the management of head and neck cancer. Treatment is often complex and multimodal. New theories on its pathophysiology have allowed the development of potential treatment modalities, including the use...

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Bibliographic Details
Published in:British journal of oral & maxillofacial surgery 2012-01, Vol.50 (1), p.41-44
Main Authors: Mcleod, N.M.H, Pratt, C.A, Mellor, T.K, Brennan, P.A
Format: Article
Language:English
Subjects:
Aged
Antioxidants - administration & dosage
Antioxidants - therapeutic use
Dentistry
Female
Follow-Up Studies
Humans
Jaw Diseases - classification
Jaw Diseases - drug therapy
Male
Middle Aged
Mouth Neoplasms - radiotherapy
Neoadjuvant Therapy
Oropharyngeal Neoplasms - radiotherapy
Osteoradionecrosis - classification
Osteoradionecrosis - drug therapy
Pentoxifylline - administration & dosage
Pentoxifylline - therapeutic use
Pentoxifylline, Tocopherol, Osteoradionecrosis, Jaw
Radiation-Protective Agents - administration & dosage
Radiation-Protective Agents - therapeutic use
Retrospective Studies
Surgery
Tocopherols - administration & dosage
Tocopherols - therapeutic use
Tongue Neoplasms - radiotherapy
Treatment Outcome
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Summary:Abstract Osteoradionecrosis of the jaw remains the most problematic consequence of radiotherapy for the management of head and neck cancer. Treatment is often complex and multimodal. New theories on its pathophysiology have allowed the development of potential treatment modalities, including the use of pentoxifylline and tocopherol. In this retrospective case series we examined the outcomes of patients with ORN prescribed pentoxifylline and tocopherol.
ISSN:0266-4356
1532-1940
DOI:10.1016/j.bjoms.2010.11.017