Assessment of biocorrelates for brain involvement in female patients with rheumatoid arthritis

Central nervous system (CNS) abnormalities are rare in patients with rheumatoid arthritis (RA). Direct studies done to investigate brain involvement in RA are few or even absent. We hypothesized that CNS is not excluded from the inflammatory disease process in RA. Thus we systematically investigated...

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Bibliographic Details
Published in:Clinical rheumatology 2012, Vol.31 (1), p.123-132
Main Authors: Hamed, Sherifa A., Selim, Zahra I., Elattar, Amal M., Elserogy, Yasser M., Ahmed, Eman A., Mohamed, Hanan O.
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - diagnosis
Arthritis, Rheumatoid - psychology
Biomarkers - blood
Brain - pathology
Brain - physiopathology
Brain Diseases - blood
Brain Diseases - complications
Brain Diseases - diagnosis
Brain Ischemia - diagnosis
Cognition - physiology
Cognition Disorders - complications
Cognition Disorders - diagnosis
Cognition Disorders - psychology
Cross-Sectional Studies
Demyelinating Diseases - diagnosis
Event-Related Potentials, P300 - physiology
Female
Humans
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Middle Aged
Nerve Growth Factors - blood
Original Article
Phosphopyruvate Hydratase - blood
Psychometrics
Rheumatology
S100 Calcium Binding Protein beta Subunit
S100 Proteins - blood
Vasculitis, Central Nervous System - diagnosis
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Summary:Central nervous system (CNS) abnormalities are rare in patients with rheumatoid arthritis (RA). Direct studies done to investigate brain involvement in RA are few or even absent. We hypothesized that CNS is not excluded from the inflammatory disease process in RA. Thus we systematically investigated markers of brain involvement in 55 females with RA. We examined patients' cognition using battery of sensitive psychometric testing [Mini-Mental State Examination, Stanford–Binet test (fourth edition) and Wechsler Memory Scale—Revised] and by recording P300 component of event-related potentials, a neurophysiological analogue. We also measured the serum levels of S100B and neuron-specific enolase (NSE), markers of glial and neuronal cells. Compared to control subjects, lower scores in cognitive testing were reported in 71% of the patients ( n =39) and abnormal P300 latency and amplitude ( P
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-011-1795-1