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Synthesis and Biological Activity of Optically Active Phenylbutenoid Dimers

The total synthesis of optically active phenylbutenoid dimers 1, 3, and ent-3 is described. The key step to access optically active cyclohexene rings was achieved by Diels–Alder reaction of chiral acryloyloxazolinone 9 and phenylbetadiene 10.

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Published in:	Journal of natural products (Washington, D.C.) D.C.), 2011-08, Vol.74 (8), p.1817-1821
Main Authors:	Chu, Jeonghyun, Suh, Dong Hoon, Lee, Gehyung, Han, Ah-Reum, Chae, Song Wha, Lee, Hwa Jeong, Seo, Eun-Kyoung, Lim, Hee-Jong
Format:	Article
Language:	English
Subjects:	Antineoplastic agents Benzene Derivatives - chemical synthesis Benzene Derivatives - chemistry Benzene Derivatives - pharmacology Biological and medical sciences Butyrates - chemical synthesis Butyrates - chemistry Butyrates - pharmacology Cyclohexenes - chemical synthesis Cyclohexenes - chemistry Cyclohexenes - pharmacology Female General aspects Humans Medical sciences Molecular Structure Pharmacology. Drug treatments Stereoisomerism
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container_title	Journal of natural products (Washington, D.C.)
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creator	Chu, Jeonghyun Suh, Dong Hoon Lee, Gehyung Han, Ah-Reum Chae, Song Wha Lee, Hwa Jeong Seo, Eun-Kyoung Lim, Hee-Jong
description	The total synthesis of optically active phenylbutenoid dimers 1, 3, and ent-3 is described. The key step to access optically active cyclohexene rings was achieved by Diels–Alder reaction of chiral acryloyloxazolinone 9 and phenylbetadiene 10.
doi_str_mv	10.1021/np100942e
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Nat. Prod</addtitle><description>The total synthesis of optically active phenylbutenoid dimers 1, 3, and ent-3 is described. The key step to access optically active cyclohexene rings was achieved by Diels–Alder reaction of chiral acryloyloxazolinone 9 and phenylbetadiene 10.</description><subject>Antineoplastic agents</subject><subject>Benzene Derivatives - chemical synthesis</subject><subject>Benzene Derivatives - chemistry</subject><subject>Benzene Derivatives - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Butyrates - chemical synthesis</subject><subject>Butyrates - chemistry</subject><subject>Butyrates - pharmacology</subject><subject>Cyclohexenes - chemical synthesis</subject><subject>Cyclohexenes - chemistry</subject><subject>Cyclohexenes - pharmacology</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Pharmacology. 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subjects	Antineoplastic agents Benzene Derivatives - chemical synthesis Benzene Derivatives - chemistry Benzene Derivatives - pharmacology Biological and medical sciences Butyrates - chemical synthesis Butyrates - chemistry Butyrates - pharmacology Cyclohexenes - chemical synthesis Cyclohexenes - chemistry Cyclohexenes - pharmacology Female General aspects Humans Medical sciences Molecular Structure Pharmacology. Drug treatments Stereoisomerism
title	Synthesis and Biological Activity of Optically Active Phenylbutenoid Dimers
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