Metastatic potential of a renal mass according to original tumour size at presentation

• Published in: BJU international 2012-01, Vol.109 (2), p.190-194
• Main Authors: Umbreit, Eric C., Shimko, Mark S., Childs, M. Adam, Lohse, Christine M., Cheville, John C., Leibovich, Bradley C., Blute, Michael L., Thompson, R. Houston
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Carcinoma, Renal Cell - mortality; Carcinoma, Renal Cell - pathology; Carcinoma, Renal Cell - secondary; Carcinoma, Renal Cell - surgery; Confidence intervals; Female; Follow-Up Studies; Humans; kidney neoplasms; Kidney Neoplasms - mortality; Kidney Neoplasms - pathology; Kidney Neoplasms - surgery; Kidneys; Male; Medical sciences; Middle Aged; Neoplasm Metastasis; neoplasm staging; Nephrectomy; Nephrology. Urinary tract diseases; Prognosis; recurrence; renal cell carcinoma; Retrospective Studies; Surgery; Survival Analysis; Treatment Outcome; Tumor Burden; Tumors; Tumors of the urinary system; Young Adult
• ISSN: 1464-4096; 1464-410X
• DOI: 10.1111/j.1464-410X.2011.10184.x

Study Type – Prognosis (case series) Level of Evidence 4 OBJECTIVE • To determine the metastatic potential of renal masses based on original tumour size. MATERIALS AND METHODS • We identified 2651 patients who had undergone surgical resection for a unilateral, sporadic renal tumour between 1990 and 2006. • Associations of tumour size with synchronous metastasis at presentation [M1 renal cell carcinoma (RCC)] and development of metastases, death from RCC, and death from any cause after surgery were evaluated using logistic and Cox proportional hazards regression. RESULTS • Of the 2651 patients studied, 182 (6.9%) presented with M1 RCC. Tumour size was significantly greater in patients with M1 RCC than in patients with M0 RCC (a median size of 10 vs 4.5 cm; P < 0.001). Only 1 of the 629 patients (0.2%) with a tumour