Improved and Safe Transcorneal Delivery of Flurbiprofen by NLC and NLC-Based Hydrogels

Flurbiprofen (FB)-loaded nanostructured lipid carriers (NLCs) based on Compritol®888 ATO (C888; FB-C888NLC) were developed for anti-inflammatory ocular therapy. NLCs prepared by high-pressure homogenization technique following a factorial design had low particle size (

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2012-02, Vol.101 (2), p.707-725
Main Authors: Gonzalez-Mira, Elisabet, Nikolić, Saša, Calpena, Ana C., Egea, M. Antonia, Souto, Eliana B., García, M. Luisa
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Biological and medical sciences
Chemistry, Pharmaceutical
Cornea - metabolism
drug release
factorial design
flurbiprofen
Flurbiprofen - administration & dosage
General pharmacology
Hydrogels
In Vitro Techniques
Medical sciences
nanoparticles
nanostructured lipid carriers
ophtalmic drug delivery
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
physical stability
polymorphism
Rabbits
Rheology
X-Ray Diffraction
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Description
Summary:Flurbiprofen (FB)-loaded nanostructured lipid carriers (NLCs) based on Compritol®888 ATO (C888; FB-C888NLC) were developed for anti-inflammatory ocular therapy. NLCs prepared by high-pressure homogenization technique following a factorial design had low particle size (
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.22784