Nestin-positive hair follicle pluripotent stem cells can promote regeneration of impinged peripheral nerve injury

Nestin‐positive, keratin 15 (K15)‐negative multipotent hair follicle stem cells are located above the hair follicle bulge. We have termed this location the hair follicle pluripotent stem cell area. We have previously shown that transplantation of nestin‐expressing hair follicle stem cells can regene...

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Bibliographic Details
Published in:Journal of dermatology 2012-01, Vol.39 (1), p.33-38
Main Authors: AMOH, Yasuyuki, AKI, Ryoichi, HAMADA, Yuko, NIIYAMA, Shiro, ESHIMA, Koji, KAWAHARA, Katsumasa, SATO, Yuichi, TANI, Yoichi, HOFFMAN, Robert M., KATSUOKA, Kensei
Format: Article
Language:English
Subjects:
Animals
Hair Follicle - cytology
hair follicle pluripotent stem cell area
Hair loss
Humans
Intermediate Filament Proteins - metabolism
Lgr6
Mice
Mice, Nude
Nerve Regeneration
Nerve Tissue Proteins - metabolism
Nestin
peripheral nerve
Peripheral Nerve Injuries - therapy
Pluripotent Stem Cells - transplantation
Receptors, G-Protein-Coupled - metabolism
regeneration
RNA, Messenger - metabolism
Sciatic Neuropathy - therapy
stem cell
Stem cells
Tissue Culture Techniques
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Summary:Nestin‐positive, keratin 15 (K15)‐negative multipotent hair follicle stem cells are located above the hair follicle bulge. We have termed this location the hair follicle pluripotent stem cell area. We have previously shown that transplantation of nestin‐expressing hair follicle stem cells can regenerate peripheral nerve and spinal cord injuries. In the present study, we regenerated the impinged sciatic nerve by transplanting hair follicle pluripotent stem cells. Human hair follicle stem cells were transplanted around the impinged sciatic nerve of ICR nude (nu/nu) mice. The hair follicle stem cells were transplanted between impinged sciatic nerve fragments of the mouse where they differentiated into glial fibrillary acidic protein‐positive Schwann cells and promoted the recovery of pre‐existing axons. The regenerated sciatic nerve functionally recovered. These multipotent hair follicle stem cells thereby provide a potential accessible, autologous source of stem cells for regeneration therapy of nerves degenerated by compression between bony or other hard surfaces.
ISSN:0385-2407
1346-8138
DOI:10.1111/j.1346-8138.2011.01413.x