Exploiting the Electrophilic Properties of Indole Intermediates: New Options in Designing Asymmetric Reactions

Think electrophilic: While the classical π‐excessive indole is well‐known for its electrophilic substitutions at position C3, recent advances in asymmetric catalysis resulted in a surge in utilizing the less discussed electrophilic properties of iminium‐type intermediates (see picture) in complex an...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-01, Vol.51 (1), p.46-48
Main Authors: Loh, Charles C. J., Enders, Dieter
Format: Article
Language:English
Subjects:
asymmetric catalysis
domino reactions
gold
indoles
organocatalysis
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Summary:Think electrophilic: While the classical π‐excessive indole is well‐known for its electrophilic substitutions at position C3, recent advances in asymmetric catalysis resulted in a surge in utilizing the less discussed electrophilic properties of iminium‐type intermediates (see picture) in complex annulations of indoles. Advances in AuI catalysis also allow an umpolung of the classical indole C3 reactivity.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201107575