Dermatofibrosarcoma protuberans: Clinical diagnoses and treatment results of 260 cases in China

• Published in: Journal of surgical oncology 2012-02, Vol.105 (2), p.142-148
• Main Authors: Cai, Hong, Wang, Yanong, Wu, Jianghong, Shi, Yingqiang
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Child; Combined Modality Therapy; Dermatofibrosarcoma - diagnosis; Dermatofibrosarcoma - mortality; Dermatofibrosarcoma - therapy; dermatofibrosarcoma protuberans (DFSP); Female; Follow-Up Studies; Humans; local excision; Male; Mastectomy; Medical prognosis; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local - diagnosis; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - therapy; Neoplasm Staging; Neoplasm, Residual - diagnosis; Neoplasm, Residual - mortality; Neoplasm, Residual - therapy; Prognosis; Prospective Studies; recurrence; Survival Rate; transformed DFSP; Tumors; wide excision; Young Adult
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/jso.22000

Background and Objectives Dermatofibrosarcoma protuberans (DFSP) is a low‐grade malignant tumor but has high local recurrence rate. The objectives of this study were to analyze their clinicopathologic factors and review the experience of multidisciplinary treatments. Methods A total of 260 patients who were treated between 1985 and 2006 in Fudan University Shanghai Cancer Center were evaluated. Outcomes were compared focusing on recurrence and survival. Classical DFSP and transformed DFSP were the two subtypes. Results After local excision, 50.2% of the patients were found to have residual tumors. The recurrence rate after local excision was significantly higher than that after wide excision (45.0% vs. 8.5%, P