Relationship between body-mass index and serum folate concentrations in pregnant women

The concentration of micronutrients impacts fetal development and pregnancy outcome and has been suggested to be negatively correlated with the body-mass index (BMI). We evaluated the relationship between BMI and the serum folate concentration in 802 and 660 Korean pregnant women in mid- and late pr...

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Bibliographic Details
Published in:European journal of clinical nutrition 2012-01, Vol.66 (1), p.136-138
Main Authors: Kim, H, Hwang, J-Y, Kim, K-N, Ha, E-H, Park, H, Ha, M, Lee, K-Y, Hong, Y-C, Tamura, T, Chang, N
Format: Article
Language:English
Subjects:
Adult
Analysis
Biological and medical sciences
Body Mass Index
Clinical Nutrition
Epidemiology
Feeding. Feeding behavior
Female
Fetal Development - physiology
Fetus
Folic acid
Folic Acid - blood
Folic Acid Deficiency - blood
Folic Acid Deficiency - complications
Fundamental and applied biological sciences. Psychology
Growth
Humans
Internal Medicine
Limiting factors
Maternal-Fetal Exchange
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Micronutrients
Middle Aged
Nutrients
Obesity - blood
Obesity - etiology
Physiological aspects
Placenta
Pregnancy
Pregnancy Complications - blood
Pregnancy Outcome
Pregnant women
Public Health
Republic of Korea
short-communication
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Women
Young Adult
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Summary:The concentration of micronutrients impacts fetal development and pregnancy outcome and has been suggested to be negatively correlated with the body-mass index (BMI). We evaluated the relationship between BMI and the serum folate concentration in 802 and 660 Korean pregnant women in mid- and late pregnancy, respectively, who participated in a multicenter prospective study. There was a significant negative correlation between BMI value and the serum folate concentration at mid- and late pregnancy ( P for trend 0.001 and 0.024, respectively). A general linear model confirmed this correlation at both time points after adjusting for gestational age and total folate intake. These findings are important as the serum folate concentration is a rate-limiting factor for placental folate transport to the fetus, and an inadequate folate supply may cause various malformations.
ISSN:0954-3007
1476-5640
DOI:10.1038/ejcn.2011.160