Magnetic Properties, Self-Temperature Rising Characteristics, and Biocompatibility of NiFe O Nanoparticles for Hyperthermia Applications

This paper reports first on the very promising self-heating and temperature rising characteristics of solid-state NiFe sub(2)O sub(4) nanoparticles for hyperthermia applications. NiFe sub(2)O sub(4) nanoparticles were prepared by using both the "high temperature thermal decomposition method (HT...

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Bibliographic Details
Published in:IEEE transactions on magnetics 2006-10, Vol.42 (10), p.2833
Main Authors: Lee, Sang Won, Bae, Seongtae, Takemura, Y, Yamashita, E, Kunisaki, J, Zurn, S, Kim, Chul Sung
Format: Article
Language:English
Subjects:
Biocompatibility
Chitosan
Circuit design
Hyperthermia
Iron compounds
Magnetic properties
Magnetism
Nanoparticles
Sol gel process
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Summary:This paper reports first on the very promising self-heating and temperature rising characteristics of solid-state NiFe sub(2)O sub(4) nanoparticles for hyperthermia applications. NiFe sub(2)O sub(4) nanoparticles were prepared by using both the "high temperature thermal decomposition method (HTTD)" and the "newly modified sol-gel" methods. The magnetic properties and cell-cytotoxic properties of the synthesized NiFe sub(2)O sub(4 ) nanoparticles were investigated to consider these nanoparticles for in vivo hyperthermia applications. The saturation magnetic moments measured by a high sensitive SQUID were between 43.0 and 47.6 emu/g. The cell survival rates of NiFe sub(2)O sub(4) and chitosan coated NiFe sub(2)O sub(4), which were determined by MTT assay, around 85 % and 98.8 %, respectively. The maximum self-heating temperature induced by our specially designed RF-MRI modified L-C circuit was 47.3degC and the frequency and magnetic field product, H sub(0)f was 1.07 times 10 super(9) Am super(-1) s super(-1 )
ISSN:0018-9464
1941-0069
DOI:10.1109/TMAG.2006.879142