Nikant Biologically Active Surgical Sutures

Nikant antimicrobial polyamide surgical sutures containing doxycycline were developed. Desorption of the drug into a model medium, "wicking," and the antibacterial activity of the sutures in vitro and in vivo were investigated. The selected method of modifying the surface of polyamide fibr...

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Bibliographic Details
Published in:Fibre chemistry 2002-09, Vol.34 (5), p.346-349
Main Authors: Shkurenko, S I, Idiatulina, T S
Format: Article
Language:English
Subjects:
Biomedical materials
Clinical medicine
Drugs
Fibres
In vivo testing
In vivo tests
Polyamide resins
Surface chemistry
Sutures
Online Access:Get full text
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Summary:Nikant antimicrobial polyamide surgical sutures containing doxycycline were developed. Desorption of the drug into a model medium, "wicking," and the antibacterial activity of the sutures in vitro and in vivo were investigated. The selected method of modifying the surface of polyamide fibres allows dosed release of the drug into the wound over 10-18 days, which demonstrates the expediency of using Nikant sutures in clinical practice.[PUBLICATION ABSTRACT]
ISSN:0015-0541
1573-8493
DOI:10.1023/A:1022159018362