Fe O Incorporated AOT-Alginate Nanoparticles for Drug Delivery

Composite nanoparticles of aerosol OT-alginate hydrogel loaded with Fe 3 O 4 and rhodamine 6G (R6G) in average diameter between 25 nm and 50 nm were synthesized by emulsification-cross-linking process and characterized by transmission electron microscopy (TEM) and SQUID magnetometery measurements. T...

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Bibliographic Details
Published in:IEEE transactions on magnetics 2008-11, Vol.44 (11), p.2800-2803
Main Authors: Sudakar, C., Dixit, A., Regmi, R., Naik, R., Lawes, G., Naik, V.M., Vaishnava, P.P., Toti, U., Panyam, J.
Format: Article
Language:English
Subjects:
Aerosols
Biomedical measurements
Coatings
Crosslinking
Drug delivery
Encapsulation
Iron
Magnetism
magnetite
Magnetization
Nanoparticles
Physics
polymer composite nanoparticles
Polymers
Rhodamine
Rhodamine 6G
Saturation (magnetic)
Saturation magnetization
superparamagnetic properties
Transmission electron microscopy
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Summary:Composite nanoparticles of aerosol OT-alginate hydrogel loaded with Fe 3 O 4 and rhodamine 6G (R6G) in average diameter between 25 nm and 50 nm were synthesized by emulsification-cross-linking process and characterized by transmission electron microscopy (TEM) and SQUID magnetometery measurements. TEM measurements show that the Fe 3 O 4 particles are uniformly distributed within AOT-alginate nanoparticles. The Ca 2+ cross-linked AOT-alginate nanoparticles loaded with Fe 3 O 4 and rhodamine showed superparamagnetic behavior at room temperature with saturation magnetization of ~50 emu/g of Fe 3 O 4 . Similar behavior was exhibited by Fe 2+ cross-linked AOT-alginate nanoparticles loaded with Fe 3 O 4 and rhodamine except it showed twice the magnetization of Ca 2+ crosslinked counterpart. A decrease in the amount of rhodamine loading for the composite nanoparticle systems as compared to the bare AOT-alginate nanoparticles was found.
ISSN:0018-9464
1941-0069
DOI:10.1109/TMAG.2008.2001324