Study on the usefulness of high-molecular-weight (HMW)-Adiponectin level check of Japanese general population upon health check: Comparison of carotid ultrasonography measurement

High-molecular-weight (HMW)-adiponectin is an active and powerful predictor of atherosclerosis. Unfortunately, there is currently no reliable epidemiological reference level data available in Japan. The current ELISA method for HMW-adiponectin measurement is tedious as it requires several sample pre...

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Bibliographic Details
Published in:Clinical biochemistry 2012-01, Vol.45 (1-2), p.72-76
Main Authors: Komatsu, Junko, Fujiwara, Mutsunori, Matsuura, Masaaki, Ito, Satoru, Oritsu, Masae
Format: Article
Language:English
Subjects:
Abdominal Fat - pathology
Adiponectin - blood
Age Factors
Aged
Atherosclerosis - diagnosis
Automation
Biological and medical sciences
Carotid Arteries - diagnostic imaging
Carotid ultrasonography
CLEIA
Female
Health Check-up
HMW-adiponectin
Humans
Investigative techniques, diagnostic techniques (general aspects)
Japan
Male
Medical sciences
Middle Aged
Molecular Weight
Reference Values
Regression Analysis
Risk Assessment
Sex Factors
Ultrasonography - methods
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Summary:High-molecular-weight (HMW)-adiponectin is an active and powerful predictor of atherosclerosis. Unfortunately, there is currently no reliable epidemiological reference level data available in Japan. The current ELISA method for HMW-adiponectin measurement is tedious as it requires several sample pre-treatment steps. We studied the reference level of HMW-adiponectin measured by a simple, fully-automated CLEIA. The study subjects were 858 men and 793 women who underwent health check-ups at a Japanese Red Cross Medical Center. We investigated the relation between HMW-adiponectin and metabolic parameters, including carotid ultrasonography. The mean values of HMW-adiponectin were 3.11±1.99μg/ml in men, and 5.52±3.07μg/ml in women. There were significant differences (p
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2011.10.013