Expanding the Azaspiro[3.3]heptane Family: Synthesis of Novel Highly Functionalized Building Blocks

The preparation of versatile azaspiro[3.3]heptanes carrying multiple exit vectors is disclosed. Expedient synthetic routes enable the straightforward access to these novel modules that are expected to have significance in drug discovery and design.

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Bibliographic Details
Published in:Organic letters 2012-01, Vol.14 (1), p.66-69
Main Authors: Burkhard, Johannes A, Guérot, Carine, Knust, Henner, Carreira, Erick M
Format: Article
Language:English
Subjects:
Aza Compounds - chemical synthesis
Ethers, Cyclic - chemistry
Heptanes - chemical synthesis
Models, Molecular
Molecular Structure
Spiro Compounds - chemical synthesis
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Description
Summary:The preparation of versatile azaspiro[3.3]heptanes carrying multiple exit vectors is disclosed. Expedient synthetic routes enable the straightforward access to these novel modules that are expected to have significance in drug discovery and design.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol2028459