Modification of lipoprotein(a) by natural dicarbonyls induced their following free radical peroxidation

Lipoprotein(a) (Lp(a)) of human plasma is a supramolecular complex similar to low density lipoprotein (LDL) particles but differing from LDL by the presence by glycoprotein(a) (apo(a)). In this paper, it is shown that Lp(a) is oxidized at a much slower rate than LDL, which may suggest that apo(a) ex...

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Published in:Doklady. Biochemistry and biophysics 2011-12, Vol.441 (1), p.287-289
Main Authors: Lankin, V. Z., Afanasieva, O. I., Konovalova, G. G., Utkina, E. A., Dmitrieva, O. A., Tikhaze, A. K., Kumskova, E. M., Pokrovsky, S. N.
Format: Article
Language:English
Subjects:
Antioxidants
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biophysics and Molecular Biology
Free radicals
Free Radicals - blood
Glyoxal - pharmacology
Humans
In Vitro Techniques
Kinetics
Life Sciences
Lipid Peroxidation - drug effects
Lipoprotein(a) - blood
Lipoprotein(a) - drug effects
Lipoproteins
Lipoproteins, LDL - blood
Lipoproteins, LDL - drug effects
Low density lipoprotein
Malondialdehyde - pharmacology
Oxidative stress
Pyruvaldehyde - pharmacology
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Summary:Lipoprotein(a) (Lp(a)) of human plasma is a supramolecular complex similar to low density lipoprotein (LDL) particles but differing from LDL by the presence by glycoprotein(a) (apo(a)). In this paper, it is shown that Lp(a) is oxidized at a much slower rate than LDL, which may suggest that apo(a) exhibits the properties of a structural antioxidant.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672911060159