Synthesis and herbicidal activities of novel 3-(substituted benzyloxy or phenoxy)-6-methyl-4-(3-trifluoromethylphenyl)pyridazine derivatives

• Published in: Pest management science 2012-02, Vol.68 (2), p.276-284
• Main Authors: Xu, Han, Zhu, You-Quan, Zou, Xiao-Mao, Liu, Bin, Wang, Yong, Hu, Fang-Zhong, Yang, Hua-Zheng
• Format: Article
• Language: English
• Subjects: 3-trifluoromethylphenyl; Biological and medical sciences; bleaching activity; Chemical synthesis; Fundamental and applied biological sciences. Psychology; herbicidal activity; Herbicides; Herbicides - chemical synthesis; Hydrocarbons; Magnoliopsida; Molecular Structure; Parasitic plants. Weeds; Phytopathology. Animal pests. Plant and forest protection; pyridazine; Pyridazines - chemistry; synthesis; Weeds
• ISSN: 1526-498X; 1526-4998
• DOI: 10.1002/ps.2257

BACKGROUND: 4‐(3‐Trifluoromethylphenyl)pyridazine represents a new series of compounds with bleaching and herbicidal activities. RESULTS: A total of 43 novel 3‐(substituted benzyloxy or phenoxy)‐6‐methyl‐4‐(3‐trifluoromethylphenyl)pyridazine derivatives were synthesised, and their bleaching and herbicidal activities were evaluated through Spirodela polyrrhiza and greenhouse tests. Some compounds exhibited excellent herbicidal activities, even at a dose of 7.5 g ha−1. CONCLUSION: The results showed that a substituted phenoxy group at the 3‐position of the pyridazine ring and the electron‐withdrawing group at the para‐position on the benzene ring were essential for high herbicidal activity. Copyright © 2011 Society of Chemical Industry