Breath-Ammonia Testing of Healthy Subjects and Patients with Cirrhosis

Background Hepatic encephalopathy (HE) is a serious neuropsychiatric complication in both acute and chronic liver disease. Aims To establish the utility of a portable noninvasive method to measure ammonia in the breath of healthy subjects and patients with HE. Methods The study included 106 subjects...

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Bibliographic Details
Published in:Digestive diseases and sciences 2012, Vol.57 (1), p.189-195
Main Authors: Adrover, R., Cocozzella, D., Ridruejo, E., García, A., Rome, J., Podestá, J. J.
Format: Article
Language:English
Subjects:
Adult
Aged
Ammonia
Ammonia - metabolism
Biochemistry
Breath Tests - instrumentation
Breath Tests - methods
Case-Control Studies
Comorbidity
Cost-Benefit Analysis
Female
Gastroenterology
Hepatic Encephalopathy - diagnosis
Hepatic Encephalopathy - etiology
Hepatic Encephalopathy - metabolism
Hepatology
Humans
Liver
Liver cirrhosis
Liver Cirrhosis - complications
Liver Cirrhosis - epidemiology
Liver Cirrhosis - metabolism
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Oncology
Original Article
Predictive Value of Tests
ROC Curve
Transplant Surgery
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Summary:Background Hepatic encephalopathy (HE) is a serious neuropsychiatric complication in both acute and chronic liver disease. Aims To establish the utility of a portable noninvasive method to measure ammonia in the breath of healthy subjects and patients with HE. Methods The study included 106 subjects: 44 women and 62 men, 51 healthy and 55 cirrhotic. The breath ammonia was measured with an electrochemical sensor and expressed in parts/billion (ppb). Results The breath ammonia in healthy subjects had an average value of 151.4 ppb (95% confidence interval [CI]: 149.4–153.4) and the average value in cirrhotic patients was 169.9 ppb (95% CI: 163.5–176.2) ( P  
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-011-1858-9