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Hemochromatosis-induced bipolar disorder: a case report
Abstract Objective A patient presenting with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, bipolar disorder was found to be affected by high iron hemochromatosis. This prompted us to explore the relation between bipolar disorder and iron overload. Method We report the case a...
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| Published in: | General hospital psychiatry 2012, Vol.34 (1), p.101.e1-101.e3 |
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| container_end_page | 101.e3 |
| container_issue | 1 |
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| container_title | General hospital psychiatry |
| container_volume | 34 |
| creator | Serata, Daniele, M.D Del Casale, Antonio, M.D Rapinesi, Chiara, M.D Mancinelli, Iginia, M.D Pompili, Pieritalo, M.D Kotzalidis, Giorgio D., M.D Aimati, Laura, Ph.D Savoja, Valeria, M.D Sani, Gabriele, M.D Simmaco, Maurizio, M.D., Ph.D Tatarelli, Roberto, M.D Girardi, Paolo, M.D |
| description | Abstract Objective A patient presenting with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, bipolar disorder was found to be affected by high iron hemochromatosis. This prompted us to explore the relation between bipolar disorder and iron overload. Method We report the case and review the peer-reviewed literature focusing on mood symptoms in patients with hemochromatosis or iron overload. Animal studies of brain effects of iron overload are summarized. High iron hemochromatosis was confirmed by genetic testing, and treatment was instituted to address iron overload. Results Patient's bipolar symptoms completely subsided after phlebotomic reduction of iron overload. Conclusion Clinicians should explore the possibility of iron overload and seek genetic confirmation of hemochromatosis in resistant bipolar disorder to avoid unnecessary medication. |
| doi_str_mv | 10.1016/j.genhosppsych.2011.04.013 |
| format | article |
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This prompted us to explore the relation between bipolar disorder and iron overload. Method We report the case and review the peer-reviewed literature focusing on mood symptoms in patients with hemochromatosis or iron overload. Animal studies of brain effects of iron overload are summarized. High iron hemochromatosis was confirmed by genetic testing, and treatment was instituted to address iron overload. Results Patient's bipolar symptoms completely subsided after phlebotomic reduction of iron overload. Conclusion Clinicians should explore the possibility of iron overload and seek genetic confirmation of hemochromatosis in resistant bipolar disorder to avoid unnecessary medication.</description><identifier>ISSN: 0163-8343</identifier><identifier>EISSN: 1873-7714</identifier><identifier>DOI: 10.1016/j.genhosppsych.2011.04.013</identifier><identifier>PMID: 21749841</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bipolar disorder ; Bipolar Disorder - etiology ; Bipolar Disorder - physiopathology ; Comorbidity ; Drug-refractory conditions ; Genetics ; Hemochromatosis ; Hemochromatosis - complications ; Hemochromatosis - diagnosis ; Hemochromatosis - genetics ; Hemochromatosis - therapy ; Humans ; Italy ; Male ; Psychiatry ; Psycho-organic syndrome ; Young Adult</subject><ispartof>General hospital psychiatry, 2012, Vol.34 (1), p.101.e1-101.e3</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-c9da08cbf278443460411923912d6b45aeef32bd21535de3b984cbfa36cfa7503</citedby><cites>FETCH-LOGICAL-c349t-c9da08cbf278443460411923912d6b45aeef32bd21535de3b984cbfa36cfa7503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21749841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serata, Daniele, M.D</creatorcontrib><creatorcontrib>Del Casale, Antonio, M.D</creatorcontrib><creatorcontrib>Rapinesi, Chiara, M.D</creatorcontrib><creatorcontrib>Mancinelli, Iginia, M.D</creatorcontrib><creatorcontrib>Pompili, Pieritalo, M.D</creatorcontrib><creatorcontrib>Kotzalidis, Giorgio D., M.D</creatorcontrib><creatorcontrib>Aimati, Laura, Ph.D</creatorcontrib><creatorcontrib>Savoja, Valeria, M.D</creatorcontrib><creatorcontrib>Sani, Gabriele, M.D</creatorcontrib><creatorcontrib>Simmaco, Maurizio, M.D., Ph.D</creatorcontrib><creatorcontrib>Tatarelli, Roberto, M.D</creatorcontrib><creatorcontrib>Girardi, Paolo, M.D</creatorcontrib><title>Hemochromatosis-induced bipolar disorder: a case report</title><title>General hospital psychiatry</title><addtitle>Gen Hosp Psychiatry</addtitle><description>Abstract Objective A patient presenting with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, bipolar disorder was found to be affected by high iron hemochromatosis. This prompted us to explore the relation between bipolar disorder and iron overload. Method We report the case and review the peer-reviewed literature focusing on mood symptoms in patients with hemochromatosis or iron overload. Animal studies of brain effects of iron overload are summarized. High iron hemochromatosis was confirmed by genetic testing, and treatment was instituted to address iron overload. Results Patient's bipolar symptoms completely subsided after phlebotomic reduction of iron overload. Conclusion Clinicians should explore the possibility of iron overload and seek genetic confirmation of hemochromatosis in resistant bipolar disorder to avoid unnecessary medication.</description><subject>Bipolar disorder</subject><subject>Bipolar Disorder - etiology</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Comorbidity</subject><subject>Drug-refractory conditions</subject><subject>Genetics</subject><subject>Hemochromatosis</subject><subject>Hemochromatosis - complications</subject><subject>Hemochromatosis - diagnosis</subject><subject>Hemochromatosis - genetics</subject><subject>Hemochromatosis - therapy</subject><subject>Humans</subject><subject>Italy</subject><subject>Male</subject><subject>Psychiatry</subject><subject>Psycho-organic syndrome</subject><subject>Young Adult</subject><issn>0163-8343</issn><issn>1873-7714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNkU1v1DAQhq0K1G5L_wKKuHBK8NjOVw9IqPQDqRIH4Gw59qTrJYmDJ0Haf49XWxDqqSdfnved8TOMvQNeAIfqw654xGkbaJ5pb7eF4AAFVwUHecI20NQyr2tQr9gmwTJvpJJn7JxoxzkvRSlP2ZmAWrWNgg2r73EMdhvDaJZAnnI_udWiyzo_h8HEzHkK0WG8ykxmDWEWcQ5xecNe92YgvHx6L9iP25vv1_f5w9e7L9efHnIrVbvktnWGN7brRd0oJVXFFUArZAvCVZ0qDWIvRecElLJ0KLu0VaKNrGxv6pLLC_b-2DvH8GtFWvToyeIwmAnDSrqFMlU20CTy6kjaGIgi9nqOfjRxr4Hrgze90_970wdvmiudvKXw26cxazei-xf9KyoBn48Aps_-9hg1WY9TMuUj2kW74F825-OzGjv4yVsz_MQ90i6scUo6NWgSmutvhwseDgjAU7xq5B_U6ppO</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Serata, Daniele, M.D</creator><creator>Del Casale, Antonio, M.D</creator><creator>Rapinesi, Chiara, M.D</creator><creator>Mancinelli, Iginia, M.D</creator><creator>Pompili, Pieritalo, M.D</creator><creator>Kotzalidis, Giorgio D., M.D</creator><creator>Aimati, Laura, Ph.D</creator><creator>Savoja, Valeria, M.D</creator><creator>Sani, Gabriele, M.D</creator><creator>Simmaco, Maurizio, M.D., Ph.D</creator><creator>Tatarelli, Roberto, M.D</creator><creator>Girardi, Paolo, M.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Hemochromatosis-induced bipolar disorder: a case report</title><author>Serata, Daniele, M.D ; 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This prompted us to explore the relation between bipolar disorder and iron overload. Method We report the case and review the peer-reviewed literature focusing on mood symptoms in patients with hemochromatosis or iron overload. Animal studies of brain effects of iron overload are summarized. High iron hemochromatosis was confirmed by genetic testing, and treatment was instituted to address iron overload. Results Patient's bipolar symptoms completely subsided after phlebotomic reduction of iron overload. Conclusion Clinicians should explore the possibility of iron overload and seek genetic confirmation of hemochromatosis in resistant bipolar disorder to avoid unnecessary medication.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21749841</pmid><doi>10.1016/j.genhosppsych.2011.04.013</doi></addata></record> |
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| subjects | Bipolar disorder Bipolar Disorder - etiology Bipolar Disorder - physiopathology Comorbidity Drug-refractory conditions Genetics Hemochromatosis Hemochromatosis - complications Hemochromatosis - diagnosis Hemochromatosis - genetics Hemochromatosis - therapy Humans Italy Male Psychiatry Psycho-organic syndrome Young Adult |
| title | Hemochromatosis-induced bipolar disorder: a case report |
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